Protective Effect of Fish Gut Hydrolysates from Olive Flounder (Paralichthys olivaceus) Surimi Byproducts Against AAPH-Induced Oxidative Stress in In Vitro and In Vivo Zebrafish Models
Protective Effect of Fish Gut Hydrolysates from Olive Flounder (Paralichthys olivaceus) Surimi Byproducts Against AAPH-Induced Oxidative Stress in In Vitro and In Vivo Zebrafish Models
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DOI：
10.1080/10498850.2022.2119909
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发表时间：
2022-09-19
影响因子：
1.6
通讯作者：
Park, Joodong
中科院分区：
文献类型：
--
作者：
Jayawardhana, H. H. A. C. K.;Oh, Jae Young;Park, Joodong
橄榄比目鱼是韩国常见的与鱼糜产业相关的鱼类，会产生大量的固体废物。为了最大限度地利用橄榄比目鱼肠（OFG）副产物，对OFG进行了酶解。对所获得的水解产物进行抗氧化活性评估，以研究自由基清除活性（RSA），并对2,2'-偶氮（2-氨基丙烷）二氯化物刺激的Vero细胞进行体外实验。在斑马鱼体内和体外模型中，Protamex水解产物显示出较强的RSA (IC50值为94.96 +/- 1.60 μ g/mL)，显著降低氧化应激。OFG副产物具有作为抗氧化剂的工业应用潜力。
Olive flounder is a common surimi industry related fish species in South Korea that generates a considerable amount of solid waste. To maximize the utilization of olive flounder gut (OFG) byproducts, OFG was subjected to enzymatic hydrolysis. Antioxidant activity of the obtained hydrolysates was evaluated to investigate radical scavenging activity (RSA), and in vitro experiments were conducted on 2,2'-azobis(2-amidinopropane) dihydrochloride-stimulated Vero cells. Protamex hydrolysates showed a strong RSA (IC50 value of 94.96 +/- 1.60 mu g/mL) with a significant reduction in oxidative stress in in vitro and in vivo zebrafish models. OFG byproducts have potential for industrial application as antioxidative agents.