The short-lived annual fish Nothobranchius furzeri shows a typical teleost aging process reinforced by high incidence of age-dependent neoplasias
The short-lived annual fish Nothobranchius furzeri shows a typical teleost aging process reinforced by high incidence of age-dependent neoplasias
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DOI：
10.1016/j.exger.2010.10.011
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发表时间：
2011-04-01
影响因子：
3.9
通讯作者：
Cellerino, Alessandro
中科院分区：
文献类型：
--
作者：
Di Cicco, Emiliano;Tozzini, Eva Terzibasi;Cellerino, Alessandro
一年生鱼类Nothobranchius furzeri是可以人工养殖的最短寿命的脊椎动物。在这里，我们进行了组织病理学分析的年龄相关的病变，在这个物种。尸检分析显示，肝脏（类似于90%），肾脏（类似于75%），心脏（类似于70%）和性腺（类似于40%）的病变与先前在小型硬骨鱼网斑花中描述的病变相似。此外，在肝脏（接近35%）和肾脏（接近25%）中观察到高的肿瘤发生率。furzeri在长寿方面表现出巨大的遗传差异。横断面分析显示，肝肿瘤的发病率有明显的年龄依赖性增加，这在短寿命菌株中加速。生殖腺的横断面分析显示，在病变的发生性别特异性差异，与男性受到更严重的影响比女性。furzeri是典型的硬骨鱼衰老过程的结果，该过程决定了体内平衡功能的系统性失效，而不是单个器官或装置的系统性失效。然而，与其他硬骨鱼不同的是，这种情况被年龄依赖性肿瘤的高发病率所加强，使该物种成为分析年龄依赖性自发肿瘤发生的分子途径的有希望的模型。(C)2010年爱思唯尔公司All rights reserved.
The annual fish Nothobranchius furzeri is the shortest-lived vertebrate which can be cultured in captivity. Here, we performed a histopathological analysis of age-related lesions in this species. Post-mortem analysis revealed lesions in liver (similar to 90%), kidney (similar to 75%), heart (similar to 70%) and gonads (similar to 40%) which are similar to those previously described in the small teleost Poecilia reticulata. In addition, a high incidence of neoplasias was observed in liver (similar to 35%) and kidney (similar to 25%).Different laboratory strains of N. furzeri show large genetic differences in longevity. Cross-sectional analysis revealed a clear age-dependent increase in the incidence of liver neoplasias which was accelerated in a short-lived strain. Cross-sectional analysis of gonads revealed sex-specific differences in the occurrence of lesions, with males being more severely affected than females.In conclusion, our analysis demonstrates that short life span in N. furzeri is a consequence of a typical teleost aging process which determines systemic failure of homeostasis functions rather than of a single organ or apparatus. Unlike other teleosts, however, this scenario is reinforced by high incidence of age-dependent neoplasias, making this species a promising model to analyze the molecular pathways of age-dependent spontaneous tumorigenesis. (C) 2010 Elsevier Inc. All rights reserved.