MATERNAL DIABETES DURING PREGNANCY - CONSEQUENCES FOR THE OFFSPRING
MATERNAL DIABETES DURING PREGNANCY - CONSEQUENCES FOR THE OFFSPRING
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DOI：
10.1002/dmr.5610060303
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发表时间：
1990-12-01
期刊：
影响因子：
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通讯作者：
VANASSCHE, FA
中科院分区：
文献类型：
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作者：
AERTS, L;HOLEMANS, K;VANASSCHE, FA
在第一代诱导轻度和重度糖尿病的妊娠大鼠中，研究了妊娠期间母体糖尿病对后代的直接和长期影响。收集了关于胎儿、新生儿和成年后代（第二代）及其对妊娠的适应情况以及胎儿和成年后代（第三代）的状况的资料。妊娠期孕妇糖尿病引起胎儿代谢的改变，其后果持续到以后的生活。人们发现糖尿病或患糖尿病的倾向会代代相传。观察到轻度和重度糖尿病对胎儿和成年后代的影响有明显的差异。与母体糖尿病的程度或成年后代糖耐量的性质无关，在怀孕（第二代）时，他们患上了轻度妊娠糖尿病。因此，他们的第三代胎儿在异常的宫内环境中发育，并表现出轻度糖尿病胎儿的典型特征。当完全长大后，它们表现出紊乱的葡萄糖耐受性。虽然这些数据不能推断人类的情况，但它们指出了糖尿病宫内环境对发育中的胎儿的影响，并证实了对后代终生的持续影响。
The immediate and long-term consequences for the offspring of maternal diabetes during pregnancy were studied in pregnant rats with induced mild and severe diabetes (first generation). Information was gathered on foetal, neonatal and adult offspring (second generation) and on their adaptation to pregnancy as well as the status of their foetal and adult offspring (third generation). Maternal diabetes during pregnancy induced alteration in foetal metabolism with consequences persisting in later life. Diabetes or a diabetogenic tendency was found to be transmitted from one generation to another. A clear divergence in the influence on foetal and adult offspring of mild versus severe maternal diabetes was observed. Independent of the degree of maternal diabetes or nature of glucose tolerance in the adult offspring, in pregnancy (second generation) they developed mild gestational diabetes. Their foetuses (third generation) therefore developed in an abnormal intrauterine milieu and displayed the typical features of foetuses from mildly diabetic dams. When fully grown they displayed a disturbed glucose tolerance. Although these data do not enable extrapolation to the situation in man they point to the impact of diabetic intrauterine milieu on the developing foetus and confirm the persisting influence on the offspring throughout life.