Dorsal, but not ventral, hippocampal lesions disrupt cocaine place conditioning
Dorsal, but not ventral, hippocampal lesions disrupt cocaine place conditioning
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DOI：
10.1097/00001756-200311140-00023
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发表时间：
2003-11-14
期刊：
影响因子：
1.7
通讯作者：
Neisewander, JL
中科院分区：
文献类型：
--
作者：
Meyers, RA;Zavala, AR;Neisewander, JL
体验可卡因的环境与药物的效果有关，然后可能会引发对可卡因的渴望。这项研究使用条件性位置偏好模型检验了海马体是否参与了这种联系。大鼠接受了双侧背侧或腹侧海马区的损伤，然后被要求将特定的环境与可卡因联系起来。在条件反射之后，背侧而不是腹侧海马区受损的大鼠未能表现出对可卡因相关环境的条件性位置偏爱。这些发现表明，背侧海马区在环境刺激与可卡因效应的联系中起着重要作用，并可能对理解可卡因条件刺激引起的渴望有重要意义。
The environment in which cocaine is experienced becomes associated with the effects of the drug and can then elicit cocaine craving. This study examined whether the hippocampus is involved in such associations using the conditioned place preference model. Rats received bilateral lesions of the dorsal or ventral hippocampus and were then conditioned to associate a particular environment with cocaine. Following conditioning, rats with lesions of the dorsal, but not ventral, hippocampus failed to demonstrate conditioned place preference for the cocaine-associated environment. These findings suggest that the dorsal hippocampus plays a role in the association of environmental stimuli with the effects of cocaine and may have important implications for understanding craving elicited by cocaine-conditioned stimuli.