Heritability of depressive symptoms: a case study using a multilevel approach.
Heritability of depressive symptoms: a case study using a multilevel approach.
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DOI：
10.1002/mpr.292
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发表时间：
2009-12
影响因子：
3.1
通讯作者：
Allore, Heather G.
中科院分区：
文献类型：
--
作者：
Byers, Amy L.;Levy, Becca R.;Kasl, Stanislav V.;Bruce, Martha L.;Allore, Heather G.
我们提供了一个使用多水平建模方法来确定抑郁症状是否受遗传因素影响的案例研究。研究这个问题的现有研究主要集中在双胞胎身上。本研究建立在文献的基础上，对大家庭中抑郁症状的遗传性进行了初步研究。同时，这项研究使用多代样本评估了在家庭研究中调整遗传力测量的必要性。样本由230个社区居住的大家庭组成，其中包括431个成年后代，包括完全兄弟姐妹、同父异母的兄弟姐妹和参加南加州大学世代纵向研究的堂兄弟姐妹。所有参与者填写流行病学研究中心抑郁量表(CES-D)。多层次分析使我们能够对大家庭的自然等级进行建模。结果表明，在这些参与者中，由于遗传差异而发生的CES-D表型变异的比例并不显著大于零[H2=8.6%，95%可信区间=0-57%，p=0.71]。我们的发现表明，未来对该样本中抑郁症状的研究可以专注于非遗传解释因素，而不需要控制遗传变异。然而，我们的研究可能受限于对普遍存在的抑郁症状的测量，这可能不会推广到终生抑郁症状。
We present a case study using a multilevel modeling approach to determine whether depressive symptoms are affected by genetic factors. Existing studies examining this question have focused on twins. The present study built on the literature by conducting a preliminary study of the heritability of depressive symptoms within extended families. At the same time, this study assessed the need for adjustment of a heritability measure in a family study using a multigenerational sample. The sample consisted of 230 community-dwelling extended families that included 431 adult offspring, comprising full siblings, half siblings and cousins that participated in the University of Southern California Longitudinal Study of Generations. All participants filled out the Center for Epidemiologic Studies Depression (CES-D) scale. The multilevel analysis allowed us to model the natural hierarchy of the extended family. Results indicate that the proportion of the phenotypic variance for CES-D that occurs due to genetic differences is not significantly larger than zero among these participants [h2 = 8.6%, 95% confidence interval (CI) = 0–57%, p = 0.71]. Our findings suggest that future studies examining depressive symptoms in this sample can focus on non-genetic explanatory factors without the necessity to control for genetic variation. However, our study may be limited by measurement of prevalent depressive symptoms, which may not generalize to lifetime depressive symptoms.
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影响因子：
6.6
作者：
KUPFER, DJ;FRANK, E;NEISWANGER, K
通讯作者：
NEISWANGER, K
影响因子：
3.1
作者：
Andrews, Gavin;Brugha, Traoloach;Slade, Timothy
通讯作者：
Slade, Timothy
影响因子：
--
作者：
Bierut, LJ;Heath, AC;Martin, NG
通讯作者：
Martin, NG
DOI：
10.1093/geronb/63.1.p33
发表时间：
2008-01-01
影响因子：
6.2
作者：
Byers, Amy L.;Levy, Becca R.;Kasl, Stanislav V.
通讯作者：
Kasl, Stanislav V.
影响因子：
2.8
作者：
Kohout, F J;Berkman, L F;Cornoni-Huntley, J
通讯作者：
Cornoni-Huntley, J