Serum Uric Acid Predicts Progression of Subclinical Coronary Atherosclerosis in Individuals Without Renal Disease
Serum Uric Acid Predicts Progression of Subclinical Coronary Atherosclerosis in Individuals Without Renal Disease
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DOI：
10.2337/dc10-1007
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发表时间：
2010-11-01
期刊：
影响因子：
16.2
通讯作者：
Snell-Bergeon, Janet K.
中科院分区：
文献类型：
--
作者：
Rodrigues, Ticiana C.;Maahs, David M.;Snell-Bergeon, Janet K.
目的-使用前瞻性1型糖尿病冠状动脉钙化（CACTI）研究的数据，检查尿酸（UA）作为冠状动脉钙化（CAC）进展的可能预测因子。研究设计和方法- CAC在基线和随访6.0 +/- 0.5年后通过电子束断层扫描测量。研究人群包括443名1型糖尿病患者和526名基线时未诊断出冠状动脉疾病的对照组。肾脏疾病的存在被定义为蛋白尿和/或低肾小球滤过率的存在。结果-在无肾脏疾病的受试者中，血清UA预测CAC进展（比值比1.30 [95% CI 1.07-1.58]，P = 0.007）独立于传统的心血管危险因素，包括糖尿病和代谢综合征的存在。血清UA水平可预测冠状动脉粥样硬化的进展，并可能有助于在无明显慢性肾脏疾病的情况下识别血管疾病的风险。
OBJECTIVE - To examine uric acid (UA) as a possible predictor of the progression of coronary artery calcification (CAC) using data from the prospective Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study.RESEARCH DESIGN AND METHODS - CAC was measured by electron beam tomography at the baseline and at a follow-up 6.0 +/- 0.5 years later. The study population included 443 participants with type 1 diabetes and 526 control subjects who were free of diagnosed coronary artery disease at baseline. The presence of renal disease was defined by the presence of albuminuria and/or low glomerular filtration rate.RESULTS - In subjects without renal disease, serum UA predicted CAC progression (odds ratio 1.30 [95% CI 1.07-1.58], P = 0.007) independent of conventional cardiovascular risk factors including diabetes and the presence of metabolic syndrome.CONCLUSIONS - Serum UA levels predict the progression of coronary atherosclerosis and may be useful in identifying who is at risk for vascular disease in the absence of significant chronic kidney disease.