Virion component of herpes simplex virus type 1 KOS interferes with early shutoff of host protein synthesis induced by herpes simplex virus type 2 186.
Virion component of herpes simplex virus type 1 KOS interferes with early shutoff of host protein synthesis induced by herpes simplex virus type 2 186.
复制标题
1 型单纯疱疹病毒 KOS 的病毒颗粒成分会干扰 2 型单纯疱疹病毒诱导的宿主蛋白质合成的早期关闭186。
DOI：
10.1128/jvi.56.1.312-316.1985
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发表时间：
1985
影响因子：
5.4
通讯作者：
Betz,JL
中科院分区：
文献类型：
--
作者：
Hill,TM;Sadler,JR;Betz,JL
Herpes simplex virus (HSV) strains HSV type 1 (HSV-1) KOS and HSV-2 186 are representative of delayed and early shutoff strains, respectively, with regard to their ability to inhibit protein synthesis in Friend erythroleukemia cells. When these cells were simultaneously infected with HSV-1 KOS and HSV-2 186, HSV-1 KOS interfered with the rapid suppression of globin synthesis induced by HSV-2 186. The observed interference was competitive and not due to exclusion of HSV-2 by HSV-1 at the level of adsorption. Furthermore, UV-irradiated HSV-1 KOS was also effective at interfering with the early shutoff function of HSV-2 186, indicating that a virion component is responsible for the observed interference.
