Optimal control and cost-effective analysis of malaria/visceral leishmaniasis co-infection.
Optimal control and cost-effective analysis of malaria/visceral leishmaniasis co-infection.
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DOI：
10.1371/journal.pone.0171102
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
ELmojtaba IM
中科院分区：
文献类型：
--
作者：
Agusto FB;ELmojtaba IM
在本文中，提出并研究了涉及疟疾/内脏利什曼病双重感染传播动力学的确定性模型。然后应用最优控制理论，以个人防护、室内滞留喷洒和扑杀受感染水库作为系统控制变量，研究遏制疾病传播的最优策略。检查了各种组合策略，以研究控制措施对疾病传播的影响。我们使用三种方法研究了所有控制策略中最具成本效益的策略：感染避免率（IAR）、平均成本效益比（ACER）和增量成本效益比（ICER）。我们的结果表明，结合所有时间相关控制变量的策略的实施是最具成本效益的控制策略。通过使用从成本目标函数、ACER 和 ICER 获得的结果进一步强调了这一结果。
In this paper, a deterministic model involving the transmission dynamics of malaria/visceral leishmaniasis co-infection is presented and studied. Optimal control theory is then applied to investigate the optimal strategies for curtailing the spread of the diseases using the use of personal protection, indoor residual spraying and culling of infected reservoirs as the system control variables. Various combination strategies were examined so as to investigate the impact of the controls on the spread of the disease. And we investigated the most cost-effective strategy of all the control strategies using three approaches, the infection averted ratio (IAR), the average cost-effectiveness ratio (ACER) and incremental cost-effectiveness ratio (ICER). Our results show that the implementation of the strategy combining all the time dependent control variables is the most cost-effective control strategy. This result is further emphasized by using the results obtained from the cost objective functional, the ACER, and the ICER.