Mexican mestizo population sub-structure: effects on genetic and forensic statistical parameters
Mexican mestizo population sub-structure: effects on genetic and forensic statistical parameters
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DOI：
10.1007/s11033-012-1888-1
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发表时间：
2012-12-01
影响因子：
2.8
通讯作者：
Gomez, Rocio
中科院分区：
文献类型：
--
作者：
Noris, Gino;Santana, Carla;Gomez, Rocio
由于墨西哥混血儿是一个混合种群，有必要确定种群的亚结构对遗传和法医参数的影响。为此，研究人员对1640个无血缘关系的墨西哥混血儿进行了15个STR基因座（CODIS加上D2S1338和D19S433）的研究。我们确定了观察到偏离Hardy-Weinberg期望的等位基因和基因型频率（15个位点中有12个，纯合子过多，1 / 3），以及明显连锁不平衡的位点对（92个位点中有13个）。对墨西哥混血儿群体进行了遗传群体分层测试，结果表明，墨西哥混血儿群体亚结构为3个亚群，亚群处于HW和连锁平衡状态。整个人群中15个位点的组合具有很高的法医效率，能够在1/10（18）中区分一个个体。我们的数据潜在地验证了这15个STR位点的使用，以建立法医身份和亲子鉴定的法律目的，并为遗传变异分析提供了一个强大的工具。然而，鉴于人口是分层的，我们强烈建议在计算父权和法医研究时使用近交系数进行校正，以避免错误的假设。
Since Mexican mestizos are an admixed population, it is necessary to determine the effects that the substructure of the population has on genetic and forensic parameters. With this aim, a study was performed with 15 STR loci (CODIS plus D2S1338 and D19S433) on 1,640 unrelated Mexican mestizos. We determine allele and genotypic frequencies observing departure from Hardy-Weinberg expectation (12 out of 15 loci, with an excess of homozygotes, Fis > 0), as well as pairs of loci in an apparent linkage disequilibrium (13 of 92 loci). We conducted a test for genetic population stratification, the results show that the Mexican mestizo population is substructured into three subgroups, which are in HW and linkage equilibrium. The combination of the 15 loci in the whole population has high forensic efficiency with the capacity to genetically discriminate one individual in one quintillion (1/10(18)). Our data potentially validates the use of these 15 STR loci to establish forensic identity and parentage testing for legal purposes, and offers a powerful tool for genetic variation analysis. However, given that the population is stratified, we highly recommend applying a correction with the inbreeding coefficient in calculations of paternity and forensic studies to avoid erroneous assumptions.