Improved dose-calculation accuracy in proton treatment planning using a simplified Monte Carlo method verified with three-dimensional measurements in an anthropomorphic phantom
Improved dose-calculation accuracy in proton treatment planning using a simplified Monte Carlo method verified with three-dimensional measurements in an anthropomorphic phantom
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DOI：
10.1088/0031-9155/55/12/018
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发表时间：
2010-06-21
影响因子：
3.5
通讯作者：
Ogino, Takashi
中科院分区：
文献类型：
--
作者：
Hotta, Kenji;Kohno, Ryosuke;Ogino, Takashi
质子肿瘤治疗计划需要一种快速、准确的剂量计算方法。我们在国家肿瘤中心东部医院的治疗计划系统中实施了一种简化的蒙特卡罗(SMC)方法，用于双散射束传输方案。SMC方法通过跟踪单个质子路径，比铅笔束算法更准确地考虑了材料中的散射效应。我们证实，SMC方法比铅笔束方法更好地再现了非均匀平板体模中的测量剂量分布。当应用于复杂的拟人体模时，SMC方法很好地再现了测量的剂量分布，满足伽玛指数分析中3 mm和3%的精度误差。在500cc的目标体积上，SMC方法需要大约30分钟才能完成计算，远远少于完全蒙特卡罗计算所需的时间。SMC方法是一种实用的计算技术，具有足够的临床应用精度。
Treatment planning for proton tumor therapy requires a fast and accurate dose-calculation method. We have implemented a simplified Monte Carlo (SMC) method in the treatment planning system of the National Cancer Center Hospital East for the double-scattering beam delivery scheme. The SMC method takes into account the scattering effect in materials more accurately than the pencil beam algorithm by tracking individual proton paths. We confirmed that the SMC method reproduced measured dose distributions in a heterogeneous slab phantom better than the pencil beam method. When applied to a complex anthropomorphic phantom, the SMC method reproduced the measured dose distribution well, satisfying an accuracy tolerance of 3 mm and 3% in the gamma index analysis. The SMC method required approximately 30 min to complete the calculation over a target volume of 500 cc, much less than the time required for the full Monte Carlo calculation. The SMC method is a candidate for a practical calculation technique with sufficient accuracy for clinical application.