Dose- response association between the triglycerides: High- density lipoprotein cholesterol ratio and type 2 diabetes mellitus risk: The rural Chinese cohort study and meta- analysis
Dose- response association between the triglycerides: High- density lipoprotein cholesterol ratio and type 2 diabetes mellitus risk: The rural Chinese cohort study and meta- analysis
复制标题
甘油三酯：高密度脂蛋白胆固醇比率与 2 型糖尿病风险之间的剂量反应关联：中国农村队列研究和荟萃分析
DOI：
10.1111/1753-0407.12836
复制
发表时间：
2019-03-01
影响因子：
4.5
通讯作者：
Hu, Dongsheng
中科院分区：
文献类型：
--
作者：
Cheng, Cheng;Liu, Yu;Hu, Dongsheng
背景高甘油三酯（TG）和低高密度脂蛋白胆固醇（HDL-C）水平是2型糖尿病（T2DM）的传统危险因素。本研究评估了TG/HDL-C比值和T2DM risk. MethodsThe study纳入了11946名来自中国农村队列研究的无基线糖尿病的成年人。采用考克斯比例风险回归分析TG/HDL-C比值与2型糖尿病的关系。用限制性三次样条分析评价剂量-反应关系。此外，合并优势比（OR）计算与随机效应模型在荟萃分析，包括本研究和另外三个合格article.ResultsDuring 2007 - 14，618例T2DM患者（9.68/1000人年）。TG/HDL-C比值最高四分位数的人比最低四分位数的人有更高的T2DM风险（校正风险比[aHR] 2.11，95%置信区间[CI] 1.55 - 2.86）;然而，女性TG/HDL-C比值与T2DM之间的相关性强于男性（aHR分别为1.27 [95% CI 1.16 - 1.39]和1.19 [95% CI 1.04 - 1.37]）。在身体质量指数特异性分析中，正常体重者的相关性比超重/肥胖者更强。剂量反应荟萃分析显示，TG/HDL-C比值增加1个单位，T2DM风险增加28%（95% CI 20%-36%），具有正线性关系结论TG/HDL-C比值是2型糖尿病的独立危险因素，尤其是女性，与2型糖尿病的危险性呈线性相关;因此，它可能是识别未来T2DM的有用指标。
BackgroundHigh triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels are traditional risk factors for type 2 diabetes mellitus (T2DM). This study evaluated the dose-response relationship between the TG/HDL-C ratio and T2DM risk.MethodsThe study included 11946 adults without baseline diabetes from the Rural Chinese Cohort Study. Cox proportional hazards regression was used to investigate the association between the TG/HDL-C ratio and T2DM. The dose-response relationship was evaluated by restricted cubic spline analysis. In addition, pooled odds ratios (OR) were calculated with a random-effects model in a meta-analysis including the present study and another three eligible articles.ResultsDuring 2007-14, 618 patients with T2DM were identified (9.68/1000 person-years). People in the highest TG/HDL-C ratio quartile had a higher T2DM risk than those in the lowest quartile (adjusted hazard ratio [aHR] 2.11, 95% confidence interval [CI] 1.55-2.86); however, the association between the TG/HDL-C ratio and T2DM was stronger in females than males (aHR 1.27 [95% CI 1.16-1.39; and 1.19 [95% CI 1.04-1.37], respectively). In body mass index-specific analysis, the association was stronger in normal weight than overweight/obese people. The dose-response meta-analysis showed that a 1-unit increment in the TG/HDL-C ratio increased the T2DM risk by 28% (95% CI 20%-36%), with a positive linear relationship (P-linear=0.326).ConclusionsThe TG/HDL-C ratio was an independent risk factor of T2DM, especially in females, and linearly increased the risk of T2DM; thus, it may be a useful indicator to identify future T2DM.