Fertility preservation for female cancer patients: early clinical experience
Fertility preservation for female cancer patients: early clinical experience
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DOI：
10.1016/j.fertnstert.2009.03.028
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发表时间：
2010-06-01
影响因子：
6.7
通讯作者：
Kazer, Ralph R.
中科院分区：
文献类型：
--
作者：
Klock, Susan C.;Zhang, John X.;Kazer, Ralph R.
目的：描述一项临床计划的早期经验，该计划旨在为即将接受化疗或放疗的女性癌症患者提供生育能力保护策略。设计：回顾性图表回顾;病例对照研究。设置：学术医学中心。患者：65名女性癌症患者和57名年龄匹配的不孕症患者。干预：参加生育能力保护计划。主要结果测量：选择积极参与，生育力保存选项的选择，进行卵母细胞提取的患者的临床结果，对胚胎disposition. Results（S）的态度：65例患者提到的程序，18个拒绝接受胚胎，卵母细胞，或组织冷冻保存。6人因医疗原因不符合资格。在剩下的41名患者中，35名选择冷冻胚胎，4名选择冷冻卵母细胞，2名选择接受卵巢组织冷冻。与年龄匹配的对照组相比，胚胎冷冻组回收的卵母细胞较少，但产生的受精卵的平均数量相似。两组对胚胎处置的态度不同。Participation. Conclusions（S）：采用现有技术的生育保留技术可能会提供安全和实用的选择，女性癌症患者面临化疗或放疗。相当数量的其他适当的参与者拒绝积极管理。与非癌症不孕症患者相比，癌症患者对胚胎处置表现出不同的态度。（Fertil Steril（R）2010;94：149-55. (C)美国生殖医学会（American Society for Reproductive Medicine）
Objective: To characterize the early experience of a clinical program designed to provide strategies for fertility preservation to female cancer patients about to undergo chemotherapy or radiation therapy.Design: Retrospective chart review; case-control study.Setting: Academic medical center.Patient(s): Sixty-five female cancer patients and 57 age-matched infertility patients.Intervention: Enrollment in a program for fertility preservation.Main Outcome Measure(s): Choice of active participation, fertility preservation option selection, clinical outcomes of patients undergoing oocyte retrieval, attitudes regarding embryo disposition.Result(s): Of 65 patients referred to the program, 18 declined to undergo embryo, oocyte, or tissue cryopreservation. Six were found not to be eligible for medical reasons. Of the remaining 41 patients, 35 chose to cryopreserve embryos, four chose to cryopreserve oocytes, and two chose to undergo ovarian tissue freezing. Fewer oocytes were recovered from the embryo cryopreservation group when compared with an age-matched control group, but the mean number of zygotes generated was similar. Attitudes regarding embryo disposition were different between the two groups. No serious clinical sequelae resulted from participation.Conclusion(s): Fertility preservation techniques employing available technology may provide safe and practical options to female cancer patients facing chemotherapy or radiation therapy. A significant number of otherwise appropriate participants decline active management. Cancer patients display different attitudes regarding embryo disposition when compared with infertility patients without cancer. (Fertil Steril (R) 2010;94:149-55. (C) 2010 by American Society for Reproductive Medicine.)