Postmortem fetal MR imaging: comparison with findings at autopsy.
Postmortem fetal MR imaging: comparison with findings at autopsy.
复制标题
死后胎儿 MR 成像：与尸检结果的比较。
DOI：
10.1097/00006254-199708000-00009
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Anne M. Kennedy
中科院分区：
文献类型：
--
作者：
Paula J. Woodward;Roya Sohaey;Dale P. Harris;G. Marc Jackson;Edward C. Klatt;Andrew L. Alexander;Anne M. Kennedy
目的
本研究的目的是前瞻性地比较尸检胎儿MR成像结果与尸检结果。
受试者和方法
26例胎儿在尸检前立即在1.5 T MR扫描仪上使用二维和高分辨率三维快速自旋回波技术进行成像。由三名放射科医生独立审查MR图像，然后评价主要和次要畸形。然后将这些结果与尸检结果进行比较。
结果
26例受试者有47例严重畸形和11例轻微畸形。所有三位放射科医生都正确识别了MR图像上的37个主要畸形（检出率，79%），并且三位审查员中至少有一位正确识别了43个异常（检出率，91%）。评审员仅识别出11个轻微异常中的1个。评审员做出了六个假阳性诊断。在两个病例中，都有重大的中枢神经系统畸形，磁共振成像优于尸检在定义原位关系。
结论
虽然尸检仍然是评估胎儿死亡原因的首选研究，但当尸检被拒绝时，MR成像是一个很好的选择。此外，磁共振成像可能是一个有价值的辅助尸检胎儿中枢神经系统异常。
OBJECTIVE
The purpose of this study was to prospectively compare findings from postmortem fetal MR imaging with findings at autopsy.
SUBJECTS AND METHODS
Twenty-six fetuses were imaged on a 1.5-T MR scanner using two-dimensional and high-resolution three-dimensional fast spin-echo techniques immediately before autopsy. The MR images were reviewed independently by three radiologists who evaluated then for major and minor malformations. These findings were then compared with those at autopsy.
RESULTS
The 26 subjects had 47 major and 11 minor malformations. All three radiologists correctly identified 37 of the major malformations on the MR images (detection rate, 79%), and at least one of the three reviewers correctly identified 43 of the abnormalities (detection rate, 91%). Only one of the 11 minor anomalies was identified by any reviewer. Reviewers made six false-positive diagnoses. In two cases, both with major CNS malformations, MR imaging was superior to autopsy in defining in situ relationships.
CONCLUSION
Although autopsy remains the study of choice for evaluating causes of fetal death, MR imaging is an excellent alternative when autopsy is refused. Additionally, MR imaging may be a valuable adjunct to autopsy for fetuses with CNS anomalies.