Sulforaphane Protects against Brain Diseases: Roles of Cytoprotective Enzymes.
Sulforaphane Protects against Brain Diseases: Roles of Cytoprotective Enzymes.
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DOI：
10.26420/austinjcerebrovascdisstroke.2017.1054
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Zhang, F
中科院分区：
文献类型：
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作者：
Sun, Y;Yang, T;Zhang, F
萝卜硫醚(SFN)是一种从西兰花和其他十字花科蔬菜中提取的异硫氰酸酯。SFN通过多靶点、多机制发挥抗氧化、抗炎、抗肿瘤等作用，引起了研究者的广泛关注。SFN最重要的靶点之一是核因子红系2相关因子2(NRF2)，它能调节一系列具有抗氧化、生存和解毒作用的细胞保护酶的表达。多项研究表明，SFN通过Nrf2途径对中枢神经系统疾病具有保护作用。本文列举了常见十字花科蔬菜中SFN的含量，并综述了SFN通过激活Nrf2信号通路对急性脑损伤和神经退行性疾病的保护作用的研究进展。
Sulforaphane (SFN) is a kind of isothiocyanate derived from broccoli and other cruciferous vegetables. Because of its roles of antioxidant, anti-inflammatory, and anti-tumor through multiple targets and various mechanisms, SFN has drawn broad attention of the researchers. One of the most important target of SFN is nuclear factor erythroid 2 related factor 2 (Nrf2), wildly known for its ability to regulate the expression of a series of cytoprotective enzymes with antioxidative, prosurvival, and detoxification effects. Multiple researches have shown that SFN protects against central nervous system diseases through Nrf2pathway. In this article, we list SFN contents in common cruciferous vegetables, and summarize recent advances in the protective effects of SFN against acute brain injuries and neurodegenerative diseases through activating Nrf2 signaling pathway.