Visuospatial versus visuomotor activity in the premotor and prefrontal cortex of a primate
Visuospatial versus visuomotor activity in the premotor and prefrontal cortex of a primate
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灵长类动物前运动皮层和前额皮质的视觉空间与视觉运动活动
DOI：
10.1523/jneurosci.13-03-01227.1993
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发表时间：
1993
影响因子：
8.6
通讯作者：
S. Wise
中科院分区：
文献类型：
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作者：
G. Pellegrino;S. Wise
当视觉空间刺激指示肢体运动时，可以说刺激具有感觉和感觉运动两个方面。我们研究了恒河猴的前运动区和前额叶区，以确定神经元活动的运动（或指令）方面的这种刺激。恒河猴根据两条规则之一选择肢体运动目标：（1）视觉空间刺激指示并触发肢体向其位置运动，或（2）相同的刺激触发向预定目标运动，而不管其位置如何。凝视和头部固定确保每个刺激出现在一个恒定的位置，在retinocentric和craniocentric坐标，以及在allocentric空间。该任务要求由某些刺激提示的空间位置必须在刺激呈现后和运动前被记住或注意。因此，在一种规则下呈现的视觉空间信息与在另一种规则下呈现的视觉空间信息的不同之处仅在于其运动（指令）意义，而不在于其注意力、空间、记忆或严格的感觉方面。因此，我们可以验证并证实这样一个假设：视觉空间线索的运动意义通常会影响前运动皮层的神经元活动，但在前额叶皮层中的影响则较少。
When visuospatial stimuli instruct a limb movement, the stimulus can be said to have both sensory and sensorimotor aspects. We studied the premotor and prefrontal areas of a rhesus monkey in order to identify neuronal activity related to the motor (or instructional) aspects of such stimuli. A rhesus monkey chose limb-movement targets according to one of two rules: (1) visuospatial stimuli instructed and triggered a limb movement toward their locations or (2) identical stimuli triggered a movement toward a predetermined target regardless of their location. Gaze and head fixation assured that each stimulus appeared at a constant location in both retinocentric and craniocentric coordinates, as well as in allocentric space. The task required that the spatial location cued by certain stimuli had to be either remembered or attended after stimulus presentation and before movement. Thus, the visuospatial information presented under one rule differed from that presented under the other only in its motor (instructional) significance and not in its attentional, spatial, mnemonic, or strictly sensory aspects. We could thereby test and confirm the hypothesis that the motor significance of visuospatial cues should commonly affect neuronal activity in the premotor cortex, but less commonly do so in the prefrontal cortex.
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