Ultrabright Fluorescent Mesoporous Silica Nanoparticles
Ultrabright Fluorescent Mesoporous Silica Nanoparticles
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DOI：
10.1002/smll.201001337
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发表时间：
2010-10-18
期刊：
影响因子：
13.3
通讯作者：
Sokolov, Igor
中科院分区：
文献类型：
--
作者：
Cho, Eun-Bum;Volkov, Dmytro O.;Sokolov, Igor
报道了首次成功合成超亮荧光介孔二氧化硅纳米粒子的方法。荧光染料被物理捕获在模板化溶胶-凝胶自组装过程中产生的二氧化硅基质的纳米通道内。通过在二氧化硅基质中引入疏水基团解决了染料从开放通道泄漏的问题。这使得该方法与几乎任何能够承受合成的染料兼容。该方法是使用染料罗丹明6 G证明。所获得的40-nm二氧化硅颗粒比30-nm涂覆的水溶性量子点亮约30倍。所述颗粒基本上比包封的有机染料本身更对光稳定。
The first successful approach to synthesizing ultrabright fluorescent mesoporous silica nanoparticles is reported. Fluorescent dye is physically entrapped inside nanochannels of a silica matrix created during templated sol-gel self-assembly. The problem of dye leakage from open channels is solved by incorporation of hydrophobic groups in the silica matrix. This makes the approach compatible with virtually any dye that can withstand the synthesis. The method is demonstrated using the dye Rhodamine 6G. The obtained 40-nm silica particles are about 30 times brighter than 30-nm coated water-soluble quantum dots. The particles are substantially more photostable than the encapsulated organic dye itself.