Chromosomal Instability in Tumor Initiation and Development.
Chromosomal Instability in Tumor Initiation and Development.
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DOI：
10.1158/0008-5472.can-18-3235
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发表时间：
2019-08-15
期刊：
影响因子：
11.2
通讯作者：
Sood AK
中科院分区：
文献类型：
--
作者：
Bach DH;Zhang W;Sood AK
染色体不稳定性（CIN）是各种人类癌症中基因组不稳定性的主要形式之一，被认为是肿瘤发生和异质性的共同标志。然而，一些恶性肿瘤显示出很少的染色体改变，这表明肿瘤的进展和进化可以在没有 CIN 的情况下发生。目前尚不清楚 CIN 在前驱病变、原发肿瘤和转移之间是否稳定，或者是否在这些步骤中演变。在这篇综述中，我们描述了 CIN 对肿瘤发生和发展各个步骤的影响。鉴于 CIN 对癌症的显着影响已得到公认，CIN 靶向治疗可能会对改善临床结果产生重大影响。
Chromosomal instability (CIN) is one of the major forms of genomic instability in various human cancers and is recognized as a common hallmark of tumorigenesis and heterogeneity. However, some malignant tumors show a paucity of chromosomal alterations, suggesting that tumor progression and evolution can occur in the absence of CIN. It is unclear whether CIN is stable between precursor lesions, primary tumor, and metastases or if it evolves during these steps. In this review, we describe the influence of CIN on the various steps in tumor initiation and development. Given the recognized significant effects of CIN in cancer, CIN-targeted therapeutics could have a major impact on improving clinical outcomes.