Ambient overnight hold of whole blood prior to the manufacture of blood components
Ambient overnight hold of whole blood prior to the manufacture of blood components
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DOI：
10.1111/j.1365-3148.2010.01025.x
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发表时间：
2010-12-01
影响因子：
1.5
通讯作者：
Thomas, Stephen
中科院分区：
文献类型：
--
作者：
Thomas, Stephen
血液服务机构通常将全血分离成不同的成分，然后在不同的条件下储存。因此，分离前用于全血的储存条件必须在红细胞（受益于冷藏）与血浆和血小板（在环境温度下更好地保存）的需求之间进行折衷。多年来，该方法一直是在采血当天生产血浆和血小板成分，并在第二天将任何未处理的血液转化为红细胞成分。然而，这可能使维持所有组件的充足库存变得具有挑战性。欧洲在处理前将全血“常温保存”长达24小时的做法使血液成分生产具有更大的灵活性，审查的数据表明，对红细胞或血浆成分的质量影响相对较小，血小板成分的质量有所改善。
Blood services routinely separate whole blood into components that are then stored under different conditions. The storage conditions used for whole blood prior to separation must therefore be a compromise between the needs of the red cells (which benefit from refrigeration) and plasma and platelets (which are better preserved at ambient temperature). For many years, the approach has been to manufacture plasma and platelet components on the day of blood collection, and to refrigerate any unprocessed blood for manufacture into red cell components on the following day. However, this can make it challenging to maintain adequate stocks of all components. The European practice of 'ambient hold' of whole blood for up to 24 hours prior to processing allows greater flexibility in blood component manufacture, and the data reviewed suggest there is relatively little impact on the quality of red cell or plasma components, and an improvement in the quality of platelet components.