Mass Changes the Diffusion Coefficient of Particles with Ligand-Receptor Contacts in the Overdamped Limit
Mass Changes the Diffusion Coefficient of Particles with Ligand-Receptor Contacts in the Overdamped Limit
复制标题
DOI：
10.1103/physrevlett.129.048003
复制
发表时间：
2022-07-21
影响因子：
8.6
通讯作者：
Holmes-Cerfon，Miranda
中科院分区：
文献类型：
--
作者：
Marbach，Sophie;Holmes-Cerfon，Miranda
惯性通常不会影响流体中被动过阻尼颗粒的长时间扩散。然而，从朗之万方程出发的模型预测了涂有配体的颗粒具有与表面受体可逆结合的令人惊讶的特性：重颗粒比相同尺寸的轻颗粒扩散得更慢。我们通过模拟并推导过阻尼极限下质量相关扩散系数的解析公式来证明这一点。我们估计了一系列生物物理配体-受体系统的这种效应的程度，并发现对于定制的微米级 DNA 包被胶体来说，这种效应是可能观察到的。
Inertia does not generally affect the long-time diffusion of passive overdamped particles in fluids. Yet a model starting from the Langevin equation predicts a surprising property of particles coated with ligands that bind reversibly to surface receptors: heavy particles diffuse more slowly than light ones of the same size. We show this by simulation and by deriving an analytic formula for the mass-dependent diffusion coefficient in the overdamped limit. We estimate the magnitude of this effect for a range of biophysical ligand-receptor systems, and find it is potentially observable for tailored micronscale DNA-coated colloids.