Combgap relays wingless signal reception to the determination of cortical cell fate in the Drosophila visual system.
Combgap relays wingless signal reception to the determination of cortical cell fate in the Drosophila visual system.
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DOI：
10.1016/s1097-2765(00)00112-x
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发表时间：
2000-11
期刊：
影响因子：
16
通讯作者：
Y. Song;S. Chung;S. Kunes
中科院分区：
文献类型：
--
作者：
Y. Song;S. Chung;S. Kunes
The dorsoventral axis of theDrosophilavisual cortex is patterned by nonautonomous signals expressed at its dorsal and ventral margins.wingless(wg) expression at the margins inducesdecapentaplegic(dpp),optomotor blind(omb), andaristalessin adjacent domains. We show that Combgap, a zinc finger protein, represses Wg target gene expression in the visual cortex. Wg signal reception downregulatescombgapexpression and derepresses target gene transcription. Combgap participates in a Hedgehog-controlled circuit in the developing wing and leg by regulating the expression of Cubitus interruptus. Combgap is thus a tissue-specific relay between Wingless and its target genes for the determination of cell fate in the visual cortex.
