Low antioxidant status of serum uric acid, bilirubin and albumin in patients with neuromyelitis optica
Low antioxidant status of serum uric acid, bilirubin and albumin in patients with neuromyelitis optica
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DOI：
10.1111/j.1468-1331.2011.03488.x
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发表时间：
2012-02-01
影响因子：
5.1
通讯作者：
Zhong, X.
中科院分区：
文献类型：
--
作者：
Peng, F.;Yang, Y.;Zhong, X.
背景：氧化应激在多发性硬化症(MS)的神经病理中起核心作用。多发性硬化症患者存在低抗氧化状态。然而，视神经脊髓炎(NMO)是一种独特的疾病实体或一种形式的MS，其与抗氧化状态之间的关系尚未得到充分研究。目的：探讨NMO与血清尿酸(UA)、胆红素、白蛋白抗氧化状态的相关性。方法：检测236例NMO和MS患者血清抗氧化剂分子UA、胆红素(Tbil、IBil)和白蛋白水平。结果：NMO患者血清UA、Tbil、IBil和白蛋白水平明显低于健康对照组。此外，当对男性和女性队列分别进行调查时，也观察到了这些结果。NMO患者血清UA、Tbil、Ibil和白蛋白水平也低于MS患者，且女性血清UA、Tbil、Ibil和白蛋白水平均低于男性。UA组女性血清UA水平明显低于男性。结论：NMO患者存在血清UA、胆红素、白蛋白水平降低。研究表明，NMO患者的抗氧化状态较低。白蛋白、胆红素、尿酸或其前体，如尿酸前体肌苷，作为患者的替代治疗，可能对NMO患者有利。
Background: Oxidative stress plays a central role in neuropathology of multiple sclerosis (MS). The patients with MS have low antioxidant status. Antioxidant therapy may represent an attractive treatment of MS. However, the relationship between neuromyelitis optica (NMO), a distinct nosologic entity or a form of MS, and antioxidant status has not fully been investigated.Objectives: To investigate the correlation between NMO and serum antioxidant status of uric acid (UA), bilirubin and albumin. Methods: The serum levels of antioxidant molecules UA, bilirubin (Tbil and Ibil) and albumin were measured in 236 individuals comprising healthy subjects and patients with NMO or MS.Results: We found that serum levels of UA, Tbil, Ibil and albumin in patients with NMO were significantly lower than those in healthy control group. Moreover, these results were also observed when the male and female cohorts were investigated separately. Likewise, the serum levels of UA, Tbil, Ibil and albumin in patients with NMO were also lower than those of patients with MS. In all groups, women had lower serum UA, Tbil, Ibil and albumin levels than men. In UA groups, women had significantly lower serum UA levels than men.Conclusion: We concluded that there were reducing serum levels of UA, bilirubin and albumin in patients with NMO. The study showed patients with NMO had low antioxidant status. As a replacement therapy to patients, administration of albumin, bilirubin and UA or theirs precursors, such as inosine of UA precursor, may be beneficial to the patients with NMO.