Increase of neuron-specific enolase in patients with Creutzfeldt-Jakob disease
Increase of neuron-specific enolase in patients with Creutzfeldt-Jakob disease
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DOI：
10.1016/s0304-3940(98)00992-6
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发表时间：
1999-02-12
影响因子：
2.5
通讯作者：
Poser, S
中科院分区：
文献类型：
--
作者：
Kropp, S;Zerr, I;Poser, S
克雅病是一种罕见的神经退行性疾病，每年发病率为1/100万，近年来，神经元特异性烯醇化酶、S-100、tau-蛋白和蛋白14-3-3等新的诊断方法被确定为蛋白病的标志物。在神经细胞迅速丢失的情况下，NSE升高，因此脑脊液中NSE的定量检测可能与疾病的进展有关。为了进一步评估这一假设，我们分析了来自16名CJD患者的纵向脑脊液样本。第一次脊椎抽吸是在神经退行性疾病的第一个临床迹象出现两周后进行的。这表明NSE升高，并在疾病过程中持续。因此，脑脊液中神经元特异性烯醇化酶的纵向检查可能有助于CJD和其他痴呆的鉴别。(C)1999由爱思唯尔科学爱尔兰有限公司出版。版权所有。
Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative human disorder with an incidence of one case per 1 000 000 per year; Recently new diagnostic tests such as neuron-specific enolase (NSE), S-100, tau-protein and protein 14-3-3 have been established as markers in prion diseases. NSE is elevated in case of rapid nerve cell loss so quantitative measurement of NSE in cerebrospinal fluid (CSF) might correlate with the disease progression. To further evaluate this hypothesis we analysed longitudinal CSF samples from -16 CJD patients. The first spinal tap was taken two weeks after the first clinical signs of a neurodegenerative disorder. This showed an elevation of NSE which continued during the course of the disease. Longitudinal examination of neuron-specific enolase in cerebrospinal fluid therefore may be useful for differentiation between CJD and other dementias. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.