Chemical Constituents of Dracocephalum forrestii
Chemical Constituents of Dracocephalum forrestii
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DOI：
10.1055/s-0029-1185868
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发表时间：
2009-12-01
期刊：
影响因子：
2.7
通讯作者：
Zhang, Wei-Dong
中科院分区：
文献类型：
--
作者：
Li, Su-Mei;Yang, Xian-Wen;Zhang, Wei-Dong
对整个植物青兰进行系统的植物化学检查，分离出 4 种新的化学成分和 65 种已知的化学成分。通过详细的一维和二维核磁共振波谱分析，新化合物被鉴定为 4-羟基-3-甲氧基苯基乙醇 8-O-[(6-O-紫丁香酰基)-β-D-吡喃葡萄糖苷] (1)、3,4,5-三甲氧基苯基乙醇 β-D-吡喃葡萄糖苷 (2)、4-O-[β-D-吡喃葡萄糖基-(1 -> 3)-α-L-吡喃鼠糖基]苯乙基肉桂酰胺(3)和9''-O-正丁基紫精酸酯(4)。评估了新分离株对 RAW 264.7 巨噬细胞中 LPS 诱导的 NO 产生的抑制活性。化合物 2 在测定浓度下表现出中等效果，没有任何细胞毒性。
A systematic phytochemical examination of the whole plant Dracocephalum forrestii led to the isolation of 4 new and 65 known chemical constituents. By detailed 1D and 2D NMR spectroscopic analyses, the new compounds were identified as 4-hydroxy-3-methoxyphenylethanol 8-O-[(6-O-syringoyl)-beta-D-glucopyranoside] (1), 3,4,5-trimethoxyphenylethanol beta-D-glucopyranoside (2), 4-O-[beta-D-glucopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl]phenylethylcinnamamide (3), and 9 ''-O-n-butyl lithospermate (4). The new isolates were evaluated for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Compound 2 revealed a moderate effect without any cytotoxicity under the assayed concentrations.