Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model
Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model
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DOI：
10.1016/j.expneurol.2009.12.017
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发表时间：
2010-04-01
影响因子：
5.3
通讯作者：
Yoshikawa, Hideki
中科院分区：
文献类型：
--
作者：
Okada, Kiyoshi;Tanaka, Hiroyuki;Yoshikawa, Hideki
甲基钴胺素是一种维生素B12类似物，是维持神经系统所必需的。尽管之前的一些研究提到了甲基钴胺素油神经元的作用，但这种作用的确切机制仍然不清楚。在这里，我们表明，浓度超过100纳米的甲基钴胺素促进神经突的生长和神经元的存活，这些作用是由甲基化循环介导的，甲基化循环是一种涉及甲基化反应的代谢途径。在大鼠坐骨神经损伤模型中，我们还证明甲基钴胺素通过甲基化循环增加Erk1/2和Akt的活性。因此，持续给予高剂量甲基钴胺素可促进神经再生和功能恢复。甲钴胺素可以通过向目标器官有效地全身或局部递送高剂量的甲钴胺素，为更好地治疗神经疾病提供基础(C) 2009 Elsevier Inc .版权所有。
Methylcobalamin is a vitamin B12 analog and is necessary for the maintenance of the nervous system Although some previous Studies have referred to the effects of methylcobalamin oil neurons, the precise mechanism of this effect remains obscure Here we show that methylcobalamin at concentrations above 100 nM promotes neurite outgrowth and neuronal survival and that these effects are mediated by the methylation cycle, a metabolic pathway involving methylation reactions. We also demonstrate that methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle In a rat sciatic nerve injury model. continuous administration of high doses of methylcobalamin Improves nerve regeneration and functional recovery Therefore. methylcobalamin may provide the basis for better treatments of nervous disorders through effective systemic or local delivery of high doses of methylcobalamin to target organs (C) 2009 Elsevier Inc All rights reserved.