Bone morphogenetic proteins and vascular differentiation - BMPing up vasculogenesis
Bone morphogenetic proteins and vascular differentiation - BMPing up vasculogenesis
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DOI：
10.1160/th05-05-0312
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发表时间：
2005-10-01
影响因子：
6.7
通讯作者：
Patterson, C
中科院分区：
文献类型：
--
作者：
Moser, M;Patterson, C
血管发生是胚胎和成人血管形成的重要机制。它可能有助于祖细胞治疗缺血性疾病如心肌梗死的修复作用。参与胚胎发育的信号通路，包括BMP通路，在成人血管发生中被重新激活。因此，有关胚胎信号事件的知识将有助于了解成人血管形成。BMP在胚胎发育中的作用在过去的几十年中得到了广泛的研究，但直到最近才认识到它们在血管发生中的作用。功能模型的获得和丧失表明BMP刺激胚胎以及成人的血管发生。此外，BMP与血管形成中涉及的其他途径相互作用，例如VEGF信号传导。研究新的分子，如BMPER，调节BMP活性，并在血管细胞中表达，将有助于了解血管发生信号，并可能开辟新的治疗途径，在血管疾病。
Vasculogenesis is an important mechanism of blood vessel formation not only in embryos but also in adults. It may contribute to reparative effects of progenitor cell therapy in ischemic diseases such as myocardial infarction. Signaling pathways involved in embryonic development, including the BMP pathway, are reactivated in adult vasculogenesis. As a consequence knowledge about embryonic signaling events will help to understand blood vessel formation in the adult. The role of BMPs in embryonic development has been studied extensively in the past decades but only recently their role in vasculogenesis has been recognized. Gain and loss of function models indicate that BMPs stimulate vasculogenesis in the embryo as well as in the adult. Additionally, BMPs interact with other pathways involved in blood vessel formation, such as VEGF signaling. Studying novel molecules such as BMPER that modulate BMP activity and that are expressed in vascular cells will help to understand vasculogenetic signaling and may open up new therapeutic avenues in vascular disease.