High AKAP8L expression predicts poor prognosis in esophageal squamous cell carcinoma.
High AKAP8L expression predicts poor prognosis in esophageal squamous cell carcinoma.
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DOI：
10.1186/s12935-022-02492-3
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发表时间：
2022-02-21
影响因子：
5.8
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Luo QY;Di T;Qiu MZ;Xia ZF;Du Y;Lin RD;Yang LQ;Sun YT;Yang DJ;Sun J;Zhang L
食管鳞状细胞癌是一种严重的疾病，死亡率高，预后差，淋巴结转移频繁。因此，迫切需要食管鳞癌的预后指标。A激酶锚蛋白8样（AKAP 8L）是A激酶锚蛋白（AKAP）家族的成员，在许多癌症中过表达。然而，AKAP 8L在ESCC中的作用仍不清楚。本研究旨在探讨AKAP 8L在食管鳞癌中的表达模式及其预后价值。从癌症基因组图谱（TCGA）和基因表达综合数据集（GEO）的数据集中分析AKAP 8L的mRNA表达。免疫组化法检测组织芯片中AKAP 8L的表达。采用Pearson卡方检验分析AKAP 8L表达与临床病理特征的相关性。单因素和多因素考克斯风险模型分析临床病理特征和AKAP 8 L表达的预后意义。生存分析采用Kaplan-Meier生存曲线。在TCGA和GEO数据集中，我们发现AKAP 8L在肿瘤组织中的mRNA水平高于癌旁组织。AKAP 8L高表达与ESCC患者的总生存期（OS）较差相关（p = 0.0039）。此外，AKAP 8L在ESCC组织芯片检测的淋巴结转移患者中高表达（p = 0.0014）。AKAP 8L高表达组与低表达组食管鳞癌临床病理特征的比较显示AKAP 8L高表达与淋巴结分期有关（p = 0.041）。Kaplan-Meier生存分析显示，AKAP 8L高表达表明ESCC患者的无进展生存期（PFS）和OS不利（p < 0.0001）。单变量和多变量分析证实AKAP 8L是ESCC患者PFS和OS的独立预后因素（p = 0.003和p < 0.0001）。总之，本研究表明AKAP 8L的高表达与ESCC的不良预后相关，并且可以被认为是ESCC的独立危险因素。
Esophageal squamous cell carcinoma (ESCC) is a severe disease with high mortality, and is associated with poor prognosis and frequent lymphatic metastasis. Therefore, prognostic indicators for ESCC are urgently needed. A-kinase anchor-protein 8-like (AKAP8L) is a member of the A kinase anchor-protein (AKAPs) family and is overexpressed in many cancers. However, the role of AKAP8L in ESCC remains unclear. The aim of this study is to investigate the expression patterns and prognostic value of AKAP8L in ESCC. The mRNA expression of AKAP8L was analyzed from the dataset of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Immunohistochemistry was applied to detect the AKAP8L expression in tissue microarray. Pearson’s chi-square test was carried out for the correlation analysis of clinicopathological features and AKAP8L expression. The prognostic significance of clinicopathological features and AKAP8L expression was determined by univariate and multivariate Cox hazard models. Kaplan–Meier survival curve was used for survival analysis. We found that the mRNA level of AKAP8L was higher in tumor tissues than in adjacent tissues in TCGA and GEO dataset. High AKAP8L expression was associated with poor overall survival (OS) in ESCC patients (p = 0.0039). Besides, AKAP8L expression was highly expressed in patients with lymph node metastasis detected by ESCC tissue microarray (p = 0.0014). The comparison of the different clinicopathological features of ESCC between high and low AKAP8L expression groups revealed that high AKAP8L expression was related to lymph node stage (p = 0.041). Kaplan–Meier survival analysis revealed that high AKAP8L expression indicates an unfavorable progression-free survival (PFS) and OS in ESCC patients (p < 0.0001). Univariate and multivariate analyses confirmed that AKAP8L was an independent prognostic factor for PFS and OS in ESCC (p = 0.003 and p < 0.0001). In conclusion, this study demonstrated that high expression of AKAP8L is associated with poor prognosis of ESCC and can be considered an independent risk factor for ESCC.
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影响因子：
10.5
作者：
Li, Yun;Kao, Gary D.;Lazar, Mitchell A.
通讯作者：
Lazar, Mitchell A.
影响因子：
2.6
作者：
Mariette, C;Finzi, L;Triboulet, JP
通讯作者：
Triboulet, JP
DOI：
10.1016/j.bbadis.2016.03.012
发表时间：
2016-06
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Hu ZY;Liu YP;Xie LY;Wang XY;Yang F;Chen SY;Li ZG
通讯作者：
Li ZG
影响因子：
2.7
作者：
Orstavik, S;Eide, T;Skålhegg, BS
通讯作者：
Skålhegg, BS
影响因子：
3.7
作者：
Eide, T;Coghlan, V;Taskén, K
通讯作者：
Taskén, K