Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancer
Effects of the type of embolization particles on carboplatin concentration in liver tumors after transcatheter arterial chemoembolization in a rabbit model of liver cancer
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DOI：
10.1097/01.rvi.0000184535.26360.5a
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发表时间：
2005-12-01
影响因子：
2.9
通讯作者：
Geschwind, JFH
中科院分区：
文献类型：
--
作者：
Hong, K;Kobeiter, H;Geschwind, JFH
目得：研究经动脉肝化疗栓塞术（TACE）中使用的颗粒类型对肝癌（VX 2）动物模型TACE后卡铂浓度的影响，并测定肿瘤、肝脏和血浆中卡铂的浓度。选择卡铂（5 mg/kg）是因为其已知的抗VX 2肿瘤效力。第1组采用三丙烯酰明胶微球（100-300 μ m）行TACE治疗，第2组采用聚乙烯醇（PVA; 150-250 μ m）行TACE治疗，第3组（对照组）动脉内注射生理盐水，第4组（药代动力学组）动脉内注射卡铂。48小时后处死动物，通过原子吸收光谱法测量血液和肝脏样品中卡铂的浓度（肿瘤和非肿瘤肝组织的中心和外周区）。第1组（三丙烯酰明胶微球）和第2组（PVA），平均卡铂浓度分别为117 μ g/g和31.8 μ g/g，在肿瘤的中心区和38.5 μ g/g对7.9 μ g/g，分别在周围区。在非肿瘤性肝组织中未检测到卡铂，两个治疗组的血浆浓度均较低（< 0.079 μ g/mL）。结论：两个治疗组中，肿瘤中心区的卡铂浓度显著高于外周区（2 ~ 4倍）。三丙烯酰明胶微球组的总体肿瘤卡铂浓度显著高于PVA组（P
PURPOSE: To study the effect of particle type used during transarterial hepatic chemoembolization (TACE) on carboplatin concentration after TACE in an animal model of liver cancer (VX2) and to determine the concentration of carboplatin within tumor, liver, and plasma.MATERIALS AND METHODS: The VX2 tumors were grown in the livers of 23 rabbits. Carboplatin (5 mg/kg) was selected because of its known potency against VX2 tumor. Group I was treated with TACE with tris-acryl gelatin microspheres (100-300 mu m), group 2 was treated with TACE with polyvinyl alcohol (PVA; 150-250 mu m), group 3 (control) was treated with intraarterial saline solution, and group 4 (pharmacokinetic) was treated with intraarterial carboplatin. Animals were killed after 48 hours, and concentrations of carboplatin were measured by atomic absorption spectroscopy from samples of blood and liver (central and peripheral zones of tumor and nontumorous liver tissue).RESULTS: In group 1 (tris-acryl gelatin microspheres) and group 2 (PVA), the mean carboplatin concentrations were 117 mu g/g and 31.8 mu g/g, respectively, within the central zone of the tumor and 38.5 mu g/g versus 7.9 mu g/g, respectively, in the peripheral zone. No carboplatin was detected in nontumorous liver tissue and plasma concentrations were low in both treated groups (< 0.079 mu g/mL).CONCLUSIONS: Carboplatin concentration was significantly greater (by a factor of two to four) within the central zone of the tumor compared with the peripheral zone in both treated groups. The overall tumor carboplatin concentrations were significantly greater in the tris-acryl gelatin microsphere group than in the PVA group (P