Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
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DOI：
10.1590/s0074-02762012000100018
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发表时间：
2012-02-01
期刊：
影响因子：
--
通讯作者：
Das, Aparup
中科院分区：
文献类型：
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作者：
Awasthi, Gauri;Satya, Godavarthi Bhogendra Krishna;Das, Aparup
Pfcrt 基因突变会改变所产生的氨基酸并形成不同的单倍型，这种突变很常见，并且与疟原虫恶性疟原虫的氯喹抗性 (CQR) 野外分离株的流行相关。这种相关性提供了通过分析 CQR Pfcrt 单倍型数据来推断 CQ 抗性的全球进化历史的机会。我们整理了来自不同全球研究的 Pfcrt 单倍型数据，并进行了进化遗传分析，以提供有关 5 个主要 CQR-Pfcrt 单倍型的全球分布以及 38 个不同国家之间进化相互关系的全面和比较信息。利用单倍型多样性数据，还确定了洲际遗传分化。
Mutations in the Pfcrt gene that change the resulting amino acids and form different haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) field isolates of the malaria parasite, Plasmodium falciparum. This correlation provides opportunities to infer the global evolutionary history of CQ resistance by analysing CQR Pfcrt haplotype data. We collated data on the Pfcrt haplotypes from different global studies and performed evolutionary genetic analysis to present comprehensive and comparative information on the global distribution of five major CQR-Pfcrt haplotypes and evolutionary inter-relationships among 38 different countries. Using the haplotype diversity data, inter-continental genetic differentiation was also ascertained.