MicroRNAs and cancer-new paradigms in molecular oncology
MicroRNAs and cancer-new paradigms in molecular oncology
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DOI：
10.1016/j.ceb.2009.03.002
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发表时间：
2009-06-01
影响因子：
7.5
通讯作者：
Calin, George A.
中科院分区：
文献类型：
--
作者：
Negrini, Massimo;Nicoloso, Milena S.;Calin, George A.
分子肿瘤学的“经典”观点表明，癌症是一种涉及肿瘤抑制蛋白和致癌蛋白的遗传疾病。然而，近年来研究表明，小的调控性非编码RNA（ncRNA）即microRNA（miRNAs）参与了人类肿瘤的发生，从而揭示了人类肿瘤分子结构的新层次。基因表达研究表明，数百种miRNA在癌细胞中失调，功能研究阐明了miRNA参与驱动肿瘤发生的所有分子和生物学过程。在这里，我们总结了miRNA参与人类癌症的最新进展，并说明了将这些知识用于医疗实践的好处。基于miRNAs的新诊断分类器将很快提供给医疗从业者，更重要的是，miRNAs可能成为新的抗癌工具。
The 'classic' view of molecular oncology indicates that cancer is a genetic disease involving tumor suppressor and oncogenic proteins. However, in the recent years, it has been demonstrated that small regulatory non-coding RNAs (ncRNAs) named microRNAs (miRNAs) are involved in human tumorigenesis, thus revealing a new layer in the molecular architecture of human cancer. Gene expression studies revealed that hundreds of miRNAs are deregulated in cancer cells and functional studies clarified that miRNAs are involved in all the molecular and biological processes that drive tumorigenesis. Here, we summarize the recent advances in miRNA involvement in human cancer and illustrate the benefits of using these knowledge for medical practice. New diagnostic classifiers based on miRNAs will soon be available for medical practitioners and, even more importantly, miRNAs may become novel anti-cancer tools.