The effect of honey-coated bandages compared with silver-coated bandages on treatment of malignant wounds-a randomized study
The effect of honey-coated bandages compared with silver-coated bandages on treatment of malignant wounds-a randomized study
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DOI：
10.1111/j.1524-475x.2011.00735.x
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发表时间：
2011-11-01
影响因子：
2.9
通讯作者：
Gottrup, Finn
中科院分区：
文献类型：
--
作者：
Lund-Nielsen, Betina;Adamsen, Lis;Gottrup, Finn
恶性伤口（MW）发生在所有癌症患者的5-10%中。恶臭和渗出是最常见的副作用。目的是确定蜂蜜涂层绷带与银涂层绷带相比对MW治疗的影响。随机选择患者进入A组（蜂蜜涂层绷带）或B组（银涂层绷带）。参数如下：伤口大小、清洁度、恶臭、渗出和伤口疼痛。数字照片、视觉模拟评分（VAS）和伤口形态登记用于基线和4周干预后的测量。纳入了69例MW和晚期癌症患者，年龄为47-90岁（中位数65.6）。两组在伤口大小、清洁度、渗出物、恶臭和伤口疼痛方面无统计学显著差异。A组和B组的伤口尺寸分别减少了15 cm（2）和8 cm（2）（p = 0.63）。根据干预后各组的汇总数据，62%的参与者在伤口尺寸方面有所改善，58%（n = 69）的参与者在清洁度方面有所改善。恶臭（p = 0.007）和渗出（p < 0.0001）的VAS评分在干预后显著改善。伤口缩小的患者中位生存时间为387天，而伤口未缩小的患者为134天（p = 0.003）。蜂蜜涂层和银涂层绷带的使用改善了MW的结果。两种方案之间无差异。两种类型的绷带都推荐用于含有肿瘤碎片和坏死的MW患者。
Malignant wounds (MWs) occur in 5-10% of all cancer patients. Malodor and exudation are the most common side effects. The aim was to determine the influence of honey-coated compared with silver-coated bandages on treatment of MWs. Patients were randomly selected to enter either group A (honey-coated bandages) or group B (silver-coated bandages). Parameters were the following: wound size, cleanliness, malodor, exudation, and wound pain. Digital photographs, visual analog scales (VAS), and wound morphology registration were used for measurement at baseline and following the 4-week intervention. Sixty-nine patients with MWs and advanced cancer, aged 47-90 (median 65.6), were included. No statistically significant difference was noted between the groups with respect to wound size, degree of cleanliness, exudation, malodor, and wound pain. There was a median decrease in wound size of 15 cm(2) and 8 cm(2) in group A and B, respectively (p = 0.63). Based on post-intervention pooled data from the groups, improvement was seen in 62% of the participants with respect to wound size and in 58% (n = 69) with respect to cleanliness. The VAS score for malodor (p = 0.007) and exudation (p < 0.0001) improved significantly post-intervention.Patients with reduced wound size had a median survival time of 387 days compared with 134 days in patients with no wound reduction (p = 0.003). The use of honey-coated and silver-coated bandages improved the outcome of MWs. No differences were found between the two regimens. Both types of bandages are recommended for use by patients with MWs containing tumor debris and necrosis.