Synthesis, X‐ray Diffraction Study, and Cytotoxicity of a Cationic p‐Cymene Ruthenium Chloro Complex Containing a Chelating Semicarbazone Ligand
Synthesis, X‐ray Diffraction Study, and Cytotoxicity of a Cationic p‐Cymene Ruthenium Chloro Complex Containing a Chelating Semicarbazone Ligand
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DOI：
10.1002/zaac.201300142
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发表时间：
2013-05
期刊：
影响因子：
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通讯作者：
Quan Zhou;Peiyuan Li;Rumei Lu;Quanquan Qian;Xiaoling Lei;Qi Xiao;Sha-Hua Huang;Lifeng Liu;Chusheng Huang;Wei Su
中科院分区：
文献类型：
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作者：
Quan Zhou;Peiyuan Li;Rumei Lu;Quanquan Qian;Xiaoling Lei;Qi Xiao;Sha-Hua Huang;Lifeng Liu;Chusheng Huang;Wei Su
一种有机金属盐，由含有螯合苯甲醛缩氨基脲配体的新的阳离子对伞花烃钌氯络合物和已知的阴离子对伞花烃钌三氯络合物组成，[（η6-p-cymene）Ru（bzsc）Cl]+[（η6-对伞花烃）RuCl 3]-（1）合成了苯甲醛缩氨基脲（bzsc = benzaldehyde semicarbazone），并通过IR、1H NMR、UV/维斯光谱、HR-ESI质谱等手段对其结构进行了表征。和元素分析测定了化合物1的单晶结构。对人胃癌细胞株SGC-7901、BEL-7404和CNE-1进行了体外抗癌活性测定，IC_（50）分别为20.7、71.1和42.6 μM。
An organometallic salt composed of a new cationic p-cymene ruthenium chloro complex containing a chelating benzaldehyde semicarbazone ligand and of the known anionic p-cymene ruthenium trichloro complex, [(η6-p-cymene)Ru(bzsc)Cl]+[(η6-p-cymene)RuCl3]– (1) (bzsc = benzaldehyde semicarbazone) was synthesized and further characterized by IR, 1H NMR, and UV/Vis spectroscopy HR-ESI mass spectrometry, and elemental analysis. The single-crystal structure of 1 was also determined. The in vitro anticancer activities of the complex was evaluated against three human cancer cell lines (SGC-7901, BEL-7404 and CNE-1), and the IC50 values were 20.7, 71.1 and 42.6 μM, respectively.