Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes
Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes
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DOI：
10.1073/pnas.0604183103
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发表时间：
2006-09-05
影响因子：
11.1
通讯作者：
Kioussis, Dimitris
中科院分区：
文献类型：
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作者：
Coles, Mark C.;Veiga-Fernandes, Henrique;Kioussis, Dimitris
淋巴结（LN）的发育取决于产前LN诱导细胞和LN组织细胞之间的相互作用。我们已经区分了由于胚胎发育失败导致的LN形成缺陷（aly/aly）和出生后成熟缺陷(Il2r γ (-/-)Rag2(-/-))。两种突变株形成正常的原始l_1，但命运不同。在aly/aly小鼠中，LN原基在妊娠后期不可逆地消散；相比之下，Il2r γ (-/-)Rag2(-/-) LN样本在出生后持续一周，但随后分散，这一过程可通过WT IL7r(+) TCR+ T或自然杀伤（NK）细胞的新生儿转移逆转，表明IL7/IL7r相互作用的作用。因此，我们揭示了出生后LN发育的一个独特阶段，在此阶段成熟淋巴细胞和IL7/IL7r相互作用可能发挥重要作用。
Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (Il2r gamma(-/-)Rag2(-/-)). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, Il2r gamma(-/-)Rag2(-/-) LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r(+) TCR+ T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role.