Interleukin-6 and development of vasospasm after subarachnoid haemorrhage
Interleukin-6 and development of vasospasm after subarachnoid haemorrhage
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DOI：
10.1007/s007010050197
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发表时间：
1998-01-01
影响因子：
2.4
通讯作者：
Yoshida, J
中科院分区：
文献类型：
--
作者：
Osuka, K;Suzuki, Y;Yoshida, J
作者对24例蛛网膜下腔出血（SAH）患者脑脊液（CSF）和9例SAH患者血清中白细胞介素-1 β（IL-1 β）、白细胞介素-6（IL-6）和白细胞介素-8（IL-8）的浓度进行了动态检测，并与临床对照。此外，在脑池内注射后，在血管造影片上分析相同细胞因子对犬脑动脉的影响。研究了注射犬CSF中类花生酸、血管生成因子和可溶性细胞粘附分子水平的变化。从SAH急性期到慢性期，CSF中IL-6和IL-8的浓度显著高于对照水平。症状性血管痉挛患者在第5天和第7天CSF中IL-6和IL-8水平显著升高。脑池内注射IL-6在8只狗中的5只中诱导了持久的血管收缩，而IL-8则没有。IL-6后犬基底动脉的直径在8小时时比预处理直径减少29 +/-5%。前列腺素E-2和I-2升高CSF的第一个4.5小时的IL-6诱导的血管痉挛。无论是血管生成因子，如血小板源性生长因子-AB和血管内皮生长因子，也不可溶性细胞粘附分子显着升高，在CSF中。IL-6，增加到非常高的浓度，在脑脊液SAH后，可能是重要的诱导血管痉挛，因为IL-6产生持久的血管收缩在犬脑动脉，这可能是部分相关的前列腺素级联的激活。
The authors characterized the role of interleukins in the cerebrospinal fluid (CSF) in the development of vasospasm after subarachnoid haemorrhage (SAH), particularly interleukin-6 (IL-6).Concentrations of interleukin-1 beta (IL-1 beta), IL-6, and interleukin-8 (IL-8) were measured serially in CSF of 24 patients and in serum of 9 patients with SAH and correlated clinically. Additionally, the effects of the same cytokines on the cerebral arteries of dogs were analyzed on angiograms after intracisternal injection. Changes in levels of eicosanoids, angiogenic factors, and soluble cell adhesion molecules were investigated in the CSF of injected dogs.CSF concentrations of IL-6 and IL-8 were elevated significantly above control levels from the acute stage of SAH until the chronic stage. Patients with symptomatic vasospasm had significantly higher levels of IL-6 as well as IL-8 in CSF on days 5 and 7. Intracisternal injection of IL-6 induced long-lasting vasoconstriction in five out of eight dogs, while IL-8 did not. The diameter of canine basilar artery after IL-6 was reduced 29 +/- 5% from pretreatment diameter at 8 hours. Prostaglandins E-2 and I-2 were elevated in CSF for the first 4.5 hour of this IL-6-induced vasospasm. Neither angioenic factors such as platelet-derived growth factor-AB and vascular endothelial growth factor nor soluble cell adhesion molecules were significantly elevated in CSF.IL-6, which increases to very high concentrations in CSF after SAH, may be important in inducing vasospasm, as IL-6 produced long-lasting vasoconstriction in the canine cerebral artery, which may be partly related to activation of the prostaglandin cascade.