The full-length genome sequences of nine HCV genotype 4 variants representing a new subtype 4s and eight unclassified lineages.
The full-length genome sequences of nine HCV genotype 4 variants representing a new subtype 4s and eight unclassified lineages.
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DOI：
10.1016/j.virol.2015.03.038
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发表时间：
2015-08
期刊：
影响因子：
3.7
通讯作者：
Murphy DG
中科院分区：
文献类型：
--
作者：
Lu L;Xu Y;Yuan J;Li C;Murphy DG
我们的特点是全长基因组的9个新的变异的HCV基因型4（HCV-4），代表一个新的亚型4s和8个未分类的谱系。它们来自居住在加拿大但都来自非洲的患者。在包含30个参考序列后，重建了扩展的最大分支可信度（MCC）树。它区分了HCV-4中的18个指定亚型和10个未分类谱系。对102个部分NS 5 B序列的类似分析产生了另一个MCC树，该MCC树揭示了22个指定的亚型（4a-4 t，4 w和4v）和30个亚型水平的未分类谱系。我们的研究表明，HCV-4在分类学上是复杂的，它显示出高度的遗传多样性，以支持非洲起源。
We characterized the full-length genomes for nine novel variants of HCV genotype 4 (HCV-4), representing a new subtype 4s and eight unclassified lineages. They were obtained from patients who resided in Canada but all had origins in Africa. An extended maximum clade credibility (MCC) tree was reconstructed after the inclusion of 30 reference sequences. It differentiated 18 assigned subtypes and 10 unclassified lineages within HCV-4. Similar analysis of 102 partial NS5B sequences resulted in another MCC tree that revealed 22 assigned subtypes (4a–4t, 4w, and 4v) and 30 unclassified lineages at the subtype level. Our study shows that HCV-4 is taxonomically complex and it displays high genetic diversity to support an African origin.