Control of homeostasis of CD8+ memory T cells by opposing cytokines
Control of homeostasis of CD8+ memory T cells by opposing cytokines
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DOI：
10.1126/science.288.5466.675
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发表时间：
2000-04-28
期刊：
影响因子：
56.9
通讯作者：
Marrack, P
中科院分区：
文献类型：
--
作者：
Ku, CC;Murakami, M;Marrack, P
在抗原暴露后，记忆T细胞在很长一段时间内保持其数量，我们在这里显示了CD8(+)记忆表型T细胞在动物体内缓慢分裂。这种分裂需要白介素15，而白介素2(IL-2)的抑制会显著增加CD8(+)记忆T细胞的数量，因此，动物体内CD8(+)记忆T细胞的数量受IL-15和IL-2之间的平衡控制。
Memory T cells maintain their numbers for long periods after antigen exposure, Here we show that CD8(+) T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2), Therefore, the numbers of CD8(+) memory T cells in animals are controlled by a balance between IL-15 and IL-2.