Amygdala mu-opioid receptors mediate the motivating influence of cue-triggered reward expectations.
Amygdala mu-opioid receptors mediate the motivating influence of cue-triggered reward expectations.
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DOI：
10.1111/ejn.13477
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Wassum KM
中科院分区：
文献类型：
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作者：
Lichtenberg NT;Wassum KM
环境奖励-预测性刺激可以从记忆中检索特定的奖励期望，使它们能够激励行动并指导选择。这一过程需要杏仁基底外侧核(BLA)，但对该结构中所需的信号系统知之甚少。在这里，我们使用结果特异性巴甫洛维-仪器转移(PIT)测试，研究了血乳酸中神经调节阿片受体系统在这种线索导向作用中的作用。研究发现，BLAµ-阿片受体的失活，而不是增量-阿片受体的失活，会剂量依赖性地减弱奖励预测线索选择性地激活针对同一唯一预测奖励的动作的能力(即表达特定结果的PIT)。BLA mu型阿片受体失活并不影响奖赏本身同样激发行为的能力(结果特异性恢复)，这表明BLA mu型阿片受体在目前无法观察到的奖赏事件的激励影响中发挥了更具选择性的作用。这些数据揭示了BLA u阿片受体激活在线索回忆精确奖赏记忆中的新作用，并利用这些信息来激励特定的行动计划。使用局部药物操作，我们发现杏仁核底部外侧MU-，而不是三角洲-阿片受体的激活是奖赏预测线索所必需的，以选择性地激活针对相同唯一预测奖赏的动作的执行。这些数据揭示了杏仁核基底外侧u-阿片受体激活在精确奖赏期望的线索回忆中的新作用，并利用这些信息来激励特定的行动计划。
Environmental reward-predictive stimuli can retrieve from memory a specific reward expectation that allows them to motivate action and guide choice. This process requires the basolateral amygdala (BLA), but little is known about the signaling systems necessary within this structure. Here we examined the role of the neuromodulatory opioid receptor system in the BLA in such cue-directed action using the outcome-specific Pavlovian-to-instrumental transfer (PIT) test in rats. Inactivation of BLA mu-, but not delta-opioid receptors was found to dose-dependently attenuate the ability of a reward-predictive cue to selectively invigorate the performance of actions directed at the same unique predicted reward (i.e. to express outcome-specific PIT). BLA mu-opioid receptor inactivation did not affect the ability of a reward itself to similarly motivate action (outcome-specific reinstatement), suggesting a more selective role for the BLA mu-opioid receptor in the motivating influence of currently unobservable rewarding events. These data reveal a new role for BLA mu-opioid receptor activation in the cued recall of precise reward memories and the use of this information to motivate specific action plans. Using local pharmacological manipulations, we found that activation of basolateral amygdala mu-, but not delta-opioid receptors is required for a reward-predictive cue to selectively invigorate the performance of actions directed at the same unique predicted reward. These data reveal a new role for basolateral amygdala mu-opioid receptor activation in the cued recall of precise reward expectations and the use of this information to motivate specific action plans.