Control of mitosis by changes in the subcellular location of cyclin-B1-Cdkw and Cdc25C
Control of mitosis by changes in the subcellular location of cyclin-B1-Cdkw and Cdc25C
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DOI：
10.1016/s0955-0674(00)00149-6
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发表时间：
2000-12-01
影响因子：
7.5
通讯作者：
Morgan, DO
中科院分区：
文献类型：
--
作者：
Takizawa, CG;Morgan, DO
当蛋白激酶cyclin-B1-Cdk 1在前期易位到细胞核中时，有丝分裂的核事件开始。最近的工作已经揭示了许多机制，管理的本地化的细胞周期蛋白B1-Cdk 1和它的调节Cdc 25 C。这些蛋白质的核输入和输出速率的磷酸化依赖性变化有助于控制正常细胞和因DNA损伤而在有丝分裂前延迟的细胞中有丝分裂的开始。
Nuclear events of mitosis are initiated when the protein kinase cyclin-B1-Cdk1 is translocated into the nucleus during prophase. Recent work has unveiled many of the mechanisms that govern the localization of cyclin-B1-Cdk1 and its regulator Cdc25C. Phosphorylation-dependent changes in the rate of nuclear import and export of these proteins help to control the onset of mitosis both in normal cells and in cells delayed before mitosis by DNA damage.