Clinical pain perception and hormone replacement therapy in postmenopausal women experiencing orofacial pain.
Clinical pain perception and hormone replacement therapy in postmenopausal women experiencing orofacial pain.
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DOI：
10.1097/00002508-200006000-00005
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发表时间：
2000-06
期刊：
影响因子：
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通讯作者：
E. A. Wise;J. Riley;M. Robinson
中科院分区：
文献类型：
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作者：
E. A. Wise;J. Riley;M. Robinson
目的研究绝经后妇女的激素替代状态与临床疼痛报告之间的关系。为了实现这一点，在口腔面部疼痛诊所进行常规慢性疼痛评估时，从87名绝经后妇女的样本中收集了疼痛评级。结果ANCOVA(控制疼痛持续时间)的结果显示，接受激素替代治疗(HRT)的绝经后妇女报告的疼痛水平高于未接受HRT治疗的绝经后妇女。数字疼痛分级量表显示，最严重疼痛报告的效果大小(0.62)，平均疼痛水平(0.48)和当前疼痛水平(0.39)的中等差异，以及最轻疼痛的微小差异(0.04)。麦吉尔疼痛问卷的效果大小显示两组之间的差异较小(0.35-0.24)。结论本研究首次探讨了女性荷尔蒙状况与临床痛觉的关系，并首次探讨了HRT在绝经后女性口腔面部疼痛临床治疗中的作用。考虑到选择在子宫切除术后或在绝经开始时开始HRT的妇女比例很高，这一调查领域尤其突出。
OBJECTIVE The purpose of this study was to examine the magnitude of the relation between a postmenopausal woman's hormonal replacement status and clinical pain report in a sample of women experiencing orofacial pain. DESIGN To accomplish this, pain ratings were collected during a routine chronic pain evaluation at an orofacial pain clinic from a sample of 87 postmenopausal women. RESULTS Results of ANCOVA (controlling for pain duration) demonstrated that postmenopausal women receiving hormone replacement therapy (HRT) reported higher levels of pain than postmenopausal women not taking HRT. Numeric pain rating scales revealed large effect sizes for worst pain report (0.62), moderate differences for average (0.48) and current (0.39) pain levels, and trivial differences for least pain (0.04). Effect sizes for the McGill Pain Questionnaire indicated somewhat smaller differences (0.35-0.24) between the two groups. CONCLUSIONS This study is among the first to examine the relation between a woman's hormonal status and clinical pain perception and is the first to investigate the role of HRT in a postmenopausal woman's orofacial pain report in a clinical treatment setting. This area of inquiry is particularly salient given the high percentage of women who choose to initiate HRT either after hysterectomy or with the onset of menopause.