Influence of fines on the surface energy heterogeneity of lactose for pulmonary drug delivery
Influence of fines on the surface energy heterogeneity of lactose for pulmonary drug delivery
复制标题
DOI：
10.1016/j.ijpharm.2009.12.037
复制
发表时间：
2010-03-30
影响因子：
5.8
通讯作者：
Heng, Jerry Y. Y.
中科院分区：
文献类型：
--
作者：
Ho, Raimundo;Muresan, Adrian S.;Heng, Jerry Y. Y.
研究了乳糖细粉的共混对粗α-乳糖一水合物载体颗粒的整体粘附性能的影响。研究了五个样品，其中三个来自 DOMO（Lactohale (R) LH100、LH210 和 LH250）的商业样品，而另外两个是 LH210 和 LH250 的混合物。表征包括粒度、SEM、PXRD 和 IGC。使用有限浓度IGC方法测定色散表面能gamma(d)(SV)以获得分布轮廓。发现乳糖晶体的 gamma(d)(SV) 分布在 40 至 48 mJ/m(2) 之间变化。未研磨的粗结晶乳糖样品 (LH100) 的 gamma(d)(SV) 最低，并且表现出比研磨样品 (LH250) 更小的异质性。发现细粉 (LH210) 具有最高的 gamma(d)(SV) 值。发现负载 LH210 的样品具有比 LH100 更高的能量。共混物 I 中 LH210 的量无法降低表面能不均匀性，而样品共混物 2 显示出足够的细粉负载，以获得相对均匀的表面。添加细粉导致γ(d)(SV)增加，表明粗乳糖表面被细粉表面取代。增加细粉的负载量可以使乳糖颗粒的表面能更加均匀。 (C) 2010 Elsevier B.V. 保留所有权利。
The effects of the blending of lactose fines to the overall adhesion property of coarse alpha-lactose monohydrate carrier particles were investigated. Five samples, three of them commercial samples from DOMO (Lactohale (R) LH100, LH210, and LH250) whilst the other two are blends of LH210 and LH250, were studied. Characterisation included particle sizing, SEM, PXRD and IGC. Dispersive surface energy gamma(d)(SV) was determined using a finite concentration IGC method to obtain a distribution profile. The gamma(d)(SV) distribution of lactose crystals was found to vary from 40 to 48 mJ/m(2). The unmilled coarse crystalline lactose sample (LH100) gamma(d)(SV) was lowest and showed less heterogeneity than the milled sample (LH250). Fines (LH210) were found to have the highest gamma(d)(SV) value. The samples with loaded LH210 were found to have a higher energy than LH100. The amount of LH210 in Blend I was not able to decrease surface energy heterogeneity, whereas sample Blend 2 showed adequate loading of fines to obtain a relatively homogeneous surface. Addition of fines resulted in an increase in gamma(d)(SV) suggesting that coarse lactose surfaces were replaced by surfaces of the fines. Increasing the loading of fines may result in a more homogeneous surface energy of lactose particles. (C) 2010 Elsevier B.V. All rights reserved.