Molecular characterization of lysyl oxidase-mediated extracellular matrix remodeling during mouse decidualization
Molecular characterization of lysyl oxidase-mediated extracellular matrix remodeling during mouse decidualization
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小鼠蜕膜化过程中赖氨酰氧化酶介导的细胞外基质重塑的分子特征
DOI：
10.1002/1873-3468.12645
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发表时间：
2017-05-01
期刊：
影响因子：
3.5
通讯作者：
Liang, Xiao-Huan
中科院分区：
文献类型：
--
作者：
Li, Shu-Yun;Yan, Jia-qi;Liang, Xiao-Huan
蜕膜化的建立是成功妊娠的先决条件。赖氨酰氧化酶（Lox）是一种含铜的胺氧化酶，其催化ECM中胶原蛋白和弹性蛋白的交联。在妊娠第5天，Lox在植入囊胚周围的腔下基质中表达。从第6天到第8天，在蜕膜细胞中检测到Lox mRNA和蛋白的强烈信号。Lox的表达受雌激素通过GSK-3 β/β-catenin/c-myc途径的调控。Dtprp通过抑制Lox活性而降低。此外，Lox活性的抑制降低了基质细胞迁移和胚胎粘附。我们的研究结果突出了Lox在子宫内膜间质细胞中的关键作用，并加深了我们对蜕膜化的理解。
The establishment of decidualization is a prerequisite of successful pregnancy. Lysyl oxidase (Lox) is a copper-containing amine oxidase which catalyzes cross-linking of collagen and elastin in the ECM. Lox is expressed in the sub-luminal stroma surrounding the implanting blastocyst on day 5 of pregnancy. From days 6 to 8, the signals for Lox mRNA and protein are strongly detected in the decidual cells. The expression of Lox is under the control of estrogen via the GSK-3 beta/beta-catenin/c-myc pathway. Dtprp is decreased by the inhibition of Lox activity. Furthermore, the inhibition of Lox activity decreases stromal cell migration and embryo adhesion. Our findings highlight the crucial role of Lox in endometrial stromal cells and deepen our understanding of decidualization.