Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction.
Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction.
复制标题
粘液溶解细菌允许病原体在饮食营养限制期间获取宿主来源的营养物质。
DOI：
10.1016/j.celrep.2022.111093
复制
发表时间：
2022
期刊：
影响因子：
8.8
通讯作者：
Alteri,Ch
中科院分区：
文献类型：
--
作者：
Sugihara,Kohei;Kitamoto,Sho;Saraithong,Prakaimuk;Nagao-Kitamoto,Hiroko;Hoostal,Matthew;McCarthy,Caroline;Rosevelt,Alexandra;Muraleedharan,ChithraK;Gillilland3rd,MerrittG;Imai,Jin;Omi,Maiko;Bishu,Shrinivas;Kao,JohnY;Alteri,Ch
病原体采用独特的代谢适应机制，以最大限度地提高其在疾病条件下的生长。粘附性侵袭性大肠杆菌（AIEC）是一种富含于炎症性肠病（IBD）患者肠粘膜的致病菌，其利用饮食来源的L-丝氨酸来适应发炎的肠道。因此，限制膳食L-丝氨酸使AIEC饥饿并限制其适合性优势。在这里，我们发现AIEC可以通过在粘液溶解细菌存在下将营养源从饮食切换到宿主细胞来克服这种营养限制。在饮食来源的L-丝氨酸限制期间，粘液溶解共生体嗜粘蛋白阿克曼氏菌通过降解粘液层促进AIEC侵入上皮生态位。在上皮龛中，AIEC从结肠上皮获得L-丝氨酸并因此增殖。我们的工作表明，致病菌和肠道共生菌之间的间接代谢网络使致病菌能够克服营养限制并在肠道中茁壮成长。
Pathobionts employ unique metabolic adaptation mechanisms to maximize their growth in disease conditions. Adherent-invasiveEscherichia coli(AIEC), a pathobiont enriched in the gut mucosa of patients with inflammatory bowel disease (IBD), utilizes diet-derived L-serine to adapt to the inflamed gut. Therefore, the restriction of dietary L-serine starves AIEC and limits its fitness advantage. Here, we find that AIEC can overcome this nutrient limitation by switching the nutrient source from the diet to the host cells in the presence of mucolytic bacteria. During diet-derived L-serine restriction, the mucolytic symbiontAkkermansia muciniphilapromotes the encroachment of AIEC to the epithelial niche by degrading the mucus layer. In the epithelial niche, AIEC acquires L-serine from the colonic epithelium and thus proliferates. Our work suggests that the indirect metabolic network between pathobionts and commensal symbionts enables pathobionts to overcome nutritional restriction and thrive in the gut.