Metabolic correlates of pallidal neuronal activity in Parkinson's disease
Metabolic correlates of pallidal neuronal activity in Parkinson's disease
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DOI：
10.1093/brain/120.8.1315
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发表时间：
1997-08-01
期刊：
影响因子：
14.5
通讯作者：
Beric, A
中科院分区：
文献类型：
--
作者：
Eidelberg, D;Moeller, JR;Beric, A
我们已经使用[F-18]氟脱氧葡萄糖和PET来确定与帕金森病和相关疾病相关的特定代谢协方差模式。然而，这些异常模式的生理相关性是未知的。在这项研究中，我们使用PET测量42名清醒的未用药帕金森病患者在单侧立体定位苍白球切开术缓解症状之前的静息状态葡萄糖代谢。在相同的条件下，在同一患者术中记录苍白球（GPi）内段的自发性单单位活动。前24名患者（A组）在中等分辨率断层扫描仪（半高宽，8 mm）上扫描;随后的18名患者（B组）在更高分辨率断层扫描仪（半高宽，4.2 mm）上扫描。两组患者GPi放电频率与丘脑葡萄糖代谢呈显著正相关（A组：r = 0.41，P < 0.05; B组：r = 0.69，P < 0.005）。在B组中，基于像素的分析揭示了涉及腹侧丘脑和GPi的生理代谢相关性的显著焦点（统计参数图：P < 0.05，校正）。区域协方差分析表明，苍白球内神经元活动与一个独特的网络表达显著相关（r = 0.65，P < 0.005），该网络的特征是苍白球丘脑和脑干代谢活动的协变。我们的研究结果表明，帕金森病患者苍白球神经元放电频率的变异性与传出投射系统代谢活动的个体差异有关。
We have used [F-18]fluorodeoxyglucose and PET to identify specific metabolic covariance patterns associated with Parkinson's disease and related disorders previously. Nonetheless, the physiological correlates of these abnormal patterns are unknown. In this study we used PET to measure resting state glucose metabolism in 42 awake unmedicated Parkinson's disease patients prior to unilateral stereotaxic pallidotomy for relief of symptoms. Spontaneous single unit activity of the internal segment of the globus pallidus (GPi) was recorded intraoperatively in the same patients under identical conditions. The first 24 patients (Group A) tt ere scanned on an intermediate resolution tomograph (full width at half maximum, 8 mm); the subsequent 18 patients (Group B) were scanned on a higher resolution tomograph (full width half maximum, 4.2 mm). We found significant positive correlations between GPi firing rates and thalamic glucose metabolism in both patient groups (Group A: r = 0.41, P < 0.05; Group B: r = 0.69, P < 0.005). In Group B, pixel-based analysis disclosed a significant focus of physiological-metabolic correlation involving the ventral thalamus and the GPi (statistical parametric map: P < 0.05, corrected). Regional covariance analysis demonstrated that internal pallidal neuronal activity correlated significantly (r = 0.65, P < 0.005) with the expression of a unique network characterized by covarying pallidothalamic and brainstem metabolic activity Our findings suggest that the variability in pallidal neuronal firing rates in Parkinson's disease patients is associated with individual differences in the metabolic activity of efferent projection systems.