Fringe, Notch, and making developmental boundaries
Fringe, Notch, and making developmental boundaries
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DOI：
10.1016/s0959-437x(99)80066-5
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发表时间：
1999-08-01
影响因子：
4
通讯作者：
Irvine, KD
中科院分区：
文献类型：
--
作者：
Irvine, KD
在果蝇翅膀中，多种机制参与了特化的背腹边界细胞的定位和限制，包括边缘蛋白（Fringe）对Notch信号的调节、Notch配体的自主抑制以及努宾蛋白（Nubbin）对Notch靶基因的抑制。最近的研究表明，边缘蛋白还调节果蝇眼睛中背腹细胞之间由Notch介导的信号传导过程，沿背腹中线建立了眼睛生长和模式形成的组织者。Notch信号的边缘蛋白依赖性调节在果蝇腿部的分节和生长中也起着关键作用。已表明疯狂边缘蛋白（Lunatic Fringe）是脊椎动物体节发生所必需的，在其中它似乎是分子钟和Notch信号调节之间的关键联系。
Multiple mechanisms are involved in positioning and restricting specialized dorsal-ventral border cells in the Drosophila wing, including modulation of Notch signaling by Fringe, autonomous inhibition by Notch ligands, and inhibition of Notch target genes by Nubbin. Recent studies have revealed that Fringe also modulates a Notch-mediated signaling process between dorsal and ventral cells in the Drosophila eye, establishing an organizer of eye growth and patterning along the dorsal-ventral midline. Fringe-dependent modulation of Notch signaling also plays a key role in Drosophila leg segmentation and growth. Lunatic Fringe has been shown to be required for vertebrate somitogenesis, where it appears to act as a crucial link between a molecular clock and the regulation of Notch signaling.