INHIBITION OF INVIVO INSULIN-SECRETION BY PROSTAGLANDIN-E1
INHIBITION OF INVIVO INSULIN-SECRETION BY PROSTAGLANDIN-E1
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DOI：
10.1172/jci107766
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发表时间：
1974-01-01
影响因子：
15.9
通讯作者：
BIERMAN, EL
中科院分区：
文献类型：
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作者：
ROBERTSON, RP;GAVARESKI, DJ;BIERMAN, EL
为了确定前列腺素E1（PGE 1）输注对体内胰岛素分泌的影响，在11只麻醉犬静脉输注PGE 1（10 μg/min）之前和期间，测定静脉葡萄糖脉冲（2 g）后的血清胰岛素反应。循环胰岛素在PGE 1输注期间显著降低，显著低于对照反应。三只狗接受了PGE 1输注到胸主动脉，以防止肺和肝脏降解的PGE 1到达胰腺动脉之前，胰岛素分泌的抑制再次出现。胰岛素分泌的抑制可能与静脉注射PGE 1引起的动脉低血压的程度无关，尽管静脉注射酚妥拉明阻断α肾上腺素能，PGE 1诱导的葡萄糖刺激的胰岛素反应的抑制持续存在。通过放射免疫测定法记录了静脉输注PGE 1期间全身循环PGE水平的显著增加。这些研究表明，全身性PGE 1输注抑制胰岛素分泌，这种作用不能被证明是依赖于α肾上腺素能活性。图片
To determine the effect of prostaglandin E1(PGE1) infusion upon in vivo insulin secretion, serum insulin responses after an intravenous glucose pulse (2 g) were measured before and during an intravenous infusion of PGE1(10 μg/min) in 11 anesthetized dogs. Circulating insulin decreased significantly during PGE1infusion were significantly less than control responses. Three dogs received PGE1infusions into the thoracic aorta to preclude pulmonic and hepatic degradation of PGE1before its arrival at the pancreatic artery; inhibition of insulin secretion was again seen. Inhibition of insulin secretion could not be related to the degree of arterial hypotension induced by intravenous PGE1, and despite alpha adrenergic blockade with intravenous phentolamine, PGE1-induced inhibition of glucose-stimulated insulin responses persisted. Significant increments in systemically circulating PGE levels during intravenous PGE1infusions were documented by radioimmunoassay. These studies demonstrate that systemic PGE1infusion inhibits insulin secretion and that this effect could not be shown to be dependent upon alpha adrenergic activity.Images