Seroprevalence of Q Fever in the United States, 2003-2004
Seroprevalence of Q Fever in the United States, 2003-2004
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DOI：
10.4269/ajtmh.2009.09-0168
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发表时间：
2009-10-01
影响因子：
3.3
通讯作者：
Massung, Robert F.
中科院分区：
文献类型：
--
作者：
Anderson, Alicia D.;Kruszon-Moran, Deanna;Massung, Robert F.
我们进行了针对贝氏柯克斯体IgG抗体的血清检测（I期和II期），并分析了参加2003-2004年国家健康与营养检查调查周期的4，437名≥ 20岁成年人的问卷数据。全国Q热血清阳性率测定酶联免疫吸附试验，并确认使用免疫荧光抗体检测。在4,437名20岁以上的成年人中，贝氏柯克斯体的总体血清阳性率为3.1%（95%置信区间[CI] = 2.1-4.3%）。年龄调整的贝氏柯克斯体抗体患病率男性高于女性（分别为3.8%，95%CI = 2.7-5.2%和2.5%，95%CI = 1.5- 3.7%）。P < 0.05）。墨西哥裔美国人的抗体流行率（7.4%，95% CI = 6.6-8.3%）显著高于非西班牙裔白人（2.8%，95% CI = 1.7-4.3%）或非西班牙裔黑人（1.3%，95% CI = 0.6-2.5%）（P < 0.001）。多变量分析表明，Q热抗体阳性的风险随着年龄的增长而增加，在外国出生的人，男性和生活在贫困中的人更高。这些发现表明，美国Q热的全国血清阳性率高于根据州卫生部门向疾病控制和预防中心报告的病例数预期的水平。不同人种/种族的暴露风险的潜在差异需要进一步研究。
We performed serum testing for IgG antibodies against Coxiella burnetii (phase I and phase II) and analyzed questionnaire data from 4,437 adults >= 20 years of age who participated in the National Health and Nutrition Examination Survey 2003-2004 survey cycle. National Q fever seroprevalence was determined by enzyme-linked immunosorbent assay and confirmed by using immunofluorescent antibody testing. Overall seroprevalence for Coxiella burnetii was 3.1% (95% confidence interval [CI] = 2.1-4.3%) among 4,437 adults >= 20 years of age. Coxiella burnetii age-adjusted antibody prevalence was higher for men than for women (3.8%, 95% CI = 2.7-5.2% versus 2.5%, 95% CI = 1.5-3.7%, respectively. P < 0.05). Mexican Americans had a significantly higher antibody prevalence(7.4%, 95% CI = 6.6-8.3%) than either non-Hispanic whites (2.8%, 95% CI = 1.7-4.3%) or non-Hispanic blacks (1.3%, 95% CI = 0.6-2.5%) (P < 0.001). Multivariate analysis showed that the risk for Q fever antibody positivity increased with age and was higher among persons who were foreign-born, male, and living in poverty. These findings indicate that the national seroprevalence of Q fever in the United States is higher than expected on the basis of case numbers reported to the Centers for Disease Control and Prevention from state health departments. Potential differences in risk for exposure by race/ethnicity warrant further study.