Cardiorespiratory fitness, BMI, and risk of hypertension: The HYPGENE study
Cardiorespiratory fitness, BMI, and risk of hypertension: The HYPGENE study
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DOI：
10.1249/mss.0b013e31812e527f
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发表时间：
2007-10-01
影响因子：
4.1
通讯作者：
Blair, Steven N.
中科院分区：
文献类型：
--
作者：
Rankinen, Tuomo;Church, Timothy S.;Blair, Steven N.
简介：健康的呼吸系统和规律的身体活动与高血压的风险呈负相关，运动训练已被证明可以降低血压升高（BP）。遗传因素对耐力训练引起的血压变化的个体间差异有显著影响。然而，关于基因型与健康相互作用对高血压风险的类似数据很少。研究方法：2000年，我们开始从有氧运动中心纵向研究（ACLS）的所有同意受试者中系统收集血液样本，目的是为解决基因型与健身相互作用对各种健康相关终点的影响的研究提供资源。在这里，我们介绍了第一项基于ACLS遗传资源的研究的基本原理和设计，重点是高血压作为健康结果（HYPGENE研究），我们报告了心肺功能和体重指数（BMI）与高血压风险的关系。所有HYPGENE受试者（N = 1234）在首次门诊访视时均健康且血压正常。病例组（N = 629）在随访期间（平均8.7年）发生高血压，而对照组（N = 605）保持非高血压（平均随访10.1年）。结果如下：呼吸适应性是高血压风险的最强预测因子，每个最大代谢当量单位与19%的低风险相关（95%置信区间[95%CI]，12-24%）。每个基线BMI单位与高血压风险增加9%相关（95% CI，4-13%）。然而，当模型中还包括健身时，BMI的相关性大大减弱（比值比1.04 [95%CI，0.99-1.09]）。结论：HYPGENE研究将提供一个很好的资源来解决有关高血压遗传基础的假设，同时考虑到心肺健康水平。
Introduction: Cardiorespiratory fitness and regular physical activity are inversely associated with the risk of hypertension, and exercise training has been shown to lower elevated blood pressure (BP). Genetic factors contribute significantly to the interindividual differences in endurance training-induced changes in BP. However, similar data on the genotype-by-fitness interactions on the risk of hypertension are scarce. Methods: In 2000, we started a systematic collection of blood samples from all consenting subjects of the Aerobics Center Longitudinal Study (ACLS) with a goal to generate a resource for studies addressing genotype-by-fitness interaction effects on various health-related end points. Here, we introduce the rationale and design of the first study based on the ACLS genetics resource focusing on hypertension as the health outcome (HYPGENE study), and we report the associations of cardiorespiratory fitness and body mass index (BMI) with the risk of hypertension. All HYPGENE subjects (N = 1234) were healthy and normotensive at their first clinic visit. Cases (N = 629) developed hypertension during the follow-up period (mean 8.7 yr), whereas controls (N = 605) remained nonnotensive (mean follow-up 10.1 yr). Results: Cardiorespiratory fitness was the strongest predictor of the hypertension risk, with each maximal metabolic equivalent unit being associated with a 19% lower risk (95% confidence interval [95% CI], 12-24%). Each baseline BMI unit was associated with a 9% higher hypertension risk (95% CI, 4-13%). However, the association of BMI was greatly attenuated (odds ratio 1.04 [95% CI, 0.99-1.09]) when fitness also was included in the model. Conclusions: The HYPGENE study will provide an excellent resource to address hypotheses regarding the genetic basis of hypertension while taking cardiorespiratory fitness level into account.