Cold Atmospheric Plasma: methods of production and application in dentistry and oncology.
Cold Atmospheric Plasma: methods of production and application in dentistry and oncology.
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DOI：
10.1186/2045-9912-3-21
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发表时间：
2013-10-01
影响因子：
2.9
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Hoffmann C;Berganza C;Zhang J
冷大气等离子体是一种电离气体，最近被研究人员广泛研究，作为牙科和肿瘤学的可能治疗方法。几种不同的气体可用于产生冷大气等离子体，例如氦气、氩气、氮气、氦氧和空气。有许多方法可以产生冷大气等离子体。每种独特的方法都可以用于不同的生物医学领域。在牙科领域，研究人员主要研究等离子体产生的抗菌作用，以去除牙齿生物膜和根除口腔病原体。它已被证明，活性氧化物种，带电粒子和紫外光子发挥主要作用。冷大气等离子体也发现了一个次要的，但在牙齿美白和复合修复的重要作用。此外，已经证明冷大气等离子体通过破坏肿瘤细胞中细胞复制的S期来诱导凋亡、坏死、细胞脱离和衰老。这一独特的发现开辟了其在肿瘤学中的潜在疗法。
Cold Atmospheric Plasma is an ionized gas that has recently been extensively studied by researchers as a possible therapy in dentistry and oncology. Several different gases can be used to produce Cold Atmospheric Plasma such as Helium, Argon, Nitrogen, Heliox, and air. There are many methods of production by which cold atmospheric plasma is created. Each unique method can be used in different biomedical areas. In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens. It has been shown that reactive oxidative species, charged particles, and UV photons play the main role. Cold Atmospheric Plasma has also found a minor, but important role in tooth whitening and composite restoration. Furthermore, it has been demonstrated that Cold Atmospheric Plasma induces apoptosis, necrosis, cell detachment, and senescence by disrupting the S phase of cell replication in tumor cells. This unique finding opens up its potential therapy in oncology.