Effect of tracheostomy on lung development in fetal lambs.
Effect of tracheostomy on lung development in fetal lambs.
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气管切开术对胎羔肺发育的影响。
DOI：
10.1152/jappl.1983.55.4.1103
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Johnson,P
中科院分区：
文献类型：
--
作者：
Fewell,JE;Hislop,AA;Kitterman,JA;Johnson,P
研究了胎羊气管切开术对羔羊肺发育的影响。对7只母羊（均为双胞胎）进行全身麻醉。每组双胞胎中的一只胎仔进行气管造口术，另一只胎仔进行假手术（妊娠117-122天）。胎儿在妊娠137 - 140天之间通过剖宫产分娩。胎儿气管切开术降低了肺的重量和体积，改变了DNA浓度和腺泡的结构发育，并降低了肺的扩张性。然而，组织和气道饱和磷脂酰胆碱和肺稳定性在放气过程中没有显着影响胎儿气管切开术。胎羊气管切开术似乎改变了肺的生长，但不影响表面活性物质的形成或释放。这些数据支持这一假设，即肺容量是积极维持和肺生长促进的分泌肺液对上呼吸道的阻力在胎羊。
The effects of fetal tracheostomy on lung development in lambs have been investigated. Seven ewes, all with twin fetuses, were given a general anesthetic. One fetus in each set of twins was tracheostomized and the other fetus was sham operated (117-122 days gestation). The fetuses were delivered by cesarean section between 137 and 140 days gestation. Fetal tracheostomy decreased lung weight and volume, altered DNA concentration and the structural development of the acinus, and decreased lung distensibility. However, tissue and airway saturated phosphatidylcholine and lung stability during deflation were not significantly affected by fetal tracheostomy. It seems that tracheostomy in fetal lambs alters lung growth but does not affect the formation or release of surfactant. These data support the hypothesis that lung volume is actively maintained and lung growth promoted by the secretion of lung fluid against the resistance of the upper airway in fetal lambs.