Outcome of patients with HTLV-1-associated adult T-cell leukemia/lymphoma after SCT: a retrospective study by the EBMT LWP
Outcome of patients with HTLV-1-associated adult T-cell leukemia/lymphoma after SCT: a retrospective study by the EBMT LWP
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DOI：
10.1038/bmt.2014.143
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发表时间：
2014-10-01
影响因子：
4.8
通讯作者：
Hermine, O.
中科院分区：
文献类型：
--
作者：
Bazarbachi, A.;Cwynarski, K.;Hermine, O.
成人T细胞白血病/淋巴瘤（ATL）预后不良。ATL的allo-SCT经验似乎令人鼓舞，但仅限于日本系列。EBMT登记的回顾性分析显示21例HTLV-I血清阳性ATL，包括7例急性和12例淋巴瘤亚型。4例患者接受了auto-SCT，并迅速死于ATL。在17例allo-SCT（4例清髓性，13例强度降低）中，6例仍存活（4例SCT时为CR 1）。11例患者在2年内死亡，8例死于复发/进展，3例死于移植毒性。7例存活时间> 12个月的患者中有6例患有慢性GVHD。总体而言，这些结果表明，allo-SCT而非auto-SCT可挽救ATL患者的一个子集，支持在非日本患者中也存在移植物vs ATL效应。
Adult T-cell leukemia/lymphoma (ATL) carries a dismal prognosis. Experience with allo-SCT for ATL appears encouraging but is limited to Japanese series. This retrospective analysis of the EBMT registry revealed 21 HTLV-I seropositive ATL including 7 acute and 12 lymphoma subtypes. Four patients received auto-SCT and rapidly died from ATL. Out of 17 allo-SCT (4 myeloablative, 13 reduced intensity), 6 are still alive (4 were in CR1 at SCT). Eleven patients died within 2 years, eight from relapse/progression and three from transplant toxicity. Six of seven informative patients who lived > 12 months had chronic GVHD. Overall these results indicate that allo-SCT but not auto-SCT may salvage a subset of ATL patients, supporting the existence of graft vs ATL effect also in non-Japanese patients.