A review of the design and modification of lactoferricins and their derivatives
A review of the design and modification of lactoferricins and their derivatives
复制标题
乳铁蛋白及其衍生物的设计和修饰研究进展
DOI：
10.1007/s10534-018-0086-6
复制
发表时间：
2018-06-01
期刊：
影响因子：
3.5
通讯作者：
Wang, Jianhua
中科院分区：
文献类型：
--
作者：
Hao, Ya;Yang, Na;Wang, Jianhua
乳铁蛋白肽（Lactoferricin，Lfcin）是由乳清蛋白乳铁蛋白经酸性胃蛋白酶水解而得的一种多功能短肽。它具有有效的营养增强，抗菌，抗癌，抗病毒，抗寄生虫和抗炎活性。本文综述了Lfcin的上述生物学功能的研究优势，并重点介绍了Lfcin的分子设计和修饰。在这方面的设计和改造研究的审查，Lfcin活性衍生物和关键氨基酸残基的鉴定研究也进行了审查。近几十年来，人们对Lfcin的优化策略进行了大量的研究，本文主要介绍了Lfcin的化学修饰、环化、嵌合和聚合。通过引入d-氨基酸、乙酰化和/或酰胺化等修饰可以有效地提高化合物的活性和稳定性。由于其广泛的生物功能和应用，Lfcins具有很大的潜力，被开发为涉及营养增强以及疾病预防和治疗作用的多种功能的生物制剂。
Lactoferricin (Lfcin), a multifunction short peptide with a length of 25 residues, is derived from the whey protein lactoferrin by acidic pepsin hydrolysis. It has potent nutritional enhancement, antimicrobial, anticancer, antiviral, antiparasitic, and anti-inflammatory activities. This review describes the research advantages of the above biological functions, with attention to the molecular design and modification of Lfcin. In this examination of design and modification studies, research on the identification of Lfcin active derivatives and crucial amino acid residues is also reviewed. Many strategies for Lfcin optimization have been studied in recent decades, but we mainly introduce chemical modification, cyclization, chimera and polymerization of this peptide. Modifications such as incorporation ofd-amino acids, acetylation and/or amidation could effectively improve the activity and stability of these compounds. Due to their wide array of bio-functions and applications, Lfcins have great potential to be developed as biological agents with multiple functions involved with nutritional enhancement, as well as disease preventive and therapeutic effects.